Dissertation/ Thesis
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Early Life Exposure to Environmental Chemicals and Neurodevelopment through Childhood and Adolescence

Bibliographic Details
Title: Early Life Exposure to Environmental Chemicals and Neurodevelopment through Childhood and Adolescence
Authors: Fabbri, Lorenzo
Thesis Advisors: Maitre, Léa, Vrijheid, Martine
Source: TDX (Tesis Doctorals en Xarxa)
Publisher Information: Universidad Pompeu Fabra, 2025.
Publication Year: 2025
Physical Description: 485 p.
Subject Terms: Disruptors endocrins, Endocrine disruptors, Disruptores endocrinos, Cohort de naixements, Birth cohort, Cohorte de nacimiento, Neurodesenvolupament, Neurodevelopment, Desarrollo neurológico, Inferència causal, Causal inference, Inferencia causal, Multiòmica, Multi-omics, Multiómica
Description: Los marcos formales de inferencia causal son necesarios para obtener estimaciones fiables de los efectos en epidemiología ambiental. Esta tesis, compuesta por tres manuscritos, promueve la implementación de varios enfoques de inferencia causal para las exposiciones ambientales y el neurodesarrollo. El primer estudio investigó las firmas moleculares asociadas con la exposición a disruptores endocrinos en la infancia. La principal innovación consistió en la integración de datos multiómicos de una submuestra profundamente caracterizada de una amplia cohorte europea. El segundo estudio investigó cómo los glucocorticosteroides podrían mediar los efectos de la exposición a disruptores endocrinos sobre la función atencional en la infancia. Las principales innovaciones incluyeron el uso del enfoque “meet-in-the-middle” y de una técnica formal de inferencia causal: la fórmula g paramétrica.
Description (Translated): Formal causal inference frameworks are necessary to obtain reliable effect estimates in environmental epidemiology. This thesis, comprising three manuscripts, advances the implementation of several causal inference approaches for environmental exposures and neurodevelopment. The first study investigated the molecular signatures associated with exposure to endocrine disrupting chemicals in childhood. The main innovation consisted in the integration of multi-omic data from a deeply characterized sub-sample of a large European cohort. The second study investigated how glucocorticosteroids might mediate the effects of exposure to endocrine disrupting chemicals on attentional function in childhood. Main innovations included the use of the meet-in-the-middle approach and of a formal causal inference technique: the parametric g-formula. The third study implemented an evidence triangulation approach to estimate causal effects of exposure to endocrine disrupting chemicals, including their mixtures, measured in pregnancy and childhood, on attentional function in adolescence. The main innovation consisted in the triangulation of evidence from several approaches to causal inference. This thesis thus enhances the implementation of formal causal inference and triangulation frameworks in the field of environmental epidemiology.
Universidad Pompeu Fabra. Doctorado en Biomedicina
Document Type: Dissertation/Thesis
File Description: application/pdf
Language: English
Access URL: http://hdl.handle.net/10803/696358
Rights: L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/
Accession Number: edstdx.10803.696358
Database: TDX
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  – Url: http://hdl.handle.net/10803/696358#
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  Data: Early Life Exposure to Environmental Chemicals and Neurodevelopment through Childhood and Adolescence
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  Data: Maitre, Léa<br />Vrijheid, Martine
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  Data: TDX (Tesis Doctorals en Xarxa)
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  Data: Universidad Pompeu Fabra, 2025.
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  Data: 2025
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  Data: 485 p.
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  Data: <searchLink fieldCode="DE" term="%22Disruptors+endocrins%22">Disruptors endocrins</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrine+disruptors%22">Endocrine disruptors</searchLink><br /><searchLink fieldCode="DE" term="%22Disruptores+endocrinos%22">Disruptores endocrinos</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+de+naixements%22">Cohort de naixements</searchLink><br /><searchLink fieldCode="DE" term="%22Birth+cohort%22">Birth cohort</searchLink><br /><searchLink fieldCode="DE" term="%22Cohorte+de+nacimiento%22">Cohorte de nacimiento</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodesenvolupament%22">Neurodesenvolupament</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodevelopment%22">Neurodevelopment</searchLink><br /><searchLink fieldCode="DE" term="%22Desarrollo+neurológico%22">Desarrollo neurológico</searchLink><br /><searchLink fieldCode="DE" term="%22Inferència+causal%22">Inferència causal</searchLink><br /><searchLink fieldCode="DE" term="%22Causal+inference%22">Causal inference</searchLink><br /><searchLink fieldCode="DE" term="%22Inferencia+causal%22">Inferencia causal</searchLink><br /><searchLink fieldCode="DE" term="%22Multiòmica%22">Multiòmica</searchLink><br /><searchLink fieldCode="DE" term="%22Multi-omics%22">Multi-omics</searchLink><br /><searchLink fieldCode="DE" term="%22Multiómica%22">Multiómica</searchLink>
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  Label: Description
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  Data: Los marcos formales de inferencia causal son necesarios para obtener estimaciones fiables de los efectos en epidemiología ambiental. Esta tesis, compuesta por tres manuscritos, promueve la implementación de varios enfoques de inferencia causal para las exposiciones ambientales y el neurodesarrollo. El primer estudio investigó las firmas moleculares asociadas con la exposición a disruptores endocrinos en la infancia. La principal innovación consistió en la integración de datos multiómicos de una submuestra profundamente caracterizada de una amplia cohorte europea. El segundo estudio investigó cómo los glucocorticosteroides podrían mediar los efectos de la exposición a disruptores endocrinos sobre la función atencional en la infancia. Las principales innovaciones incluyeron el uso del enfoque “meet-in-the-middle” y de una técnica formal de inferencia causal: la fórmula g paramétrica.
– Name: Abstract
  Label: Description (Translated)
  Group: Ab
  Data: Formal causal inference frameworks are necessary to obtain reliable effect estimates in environmental epidemiology. This thesis, comprising three manuscripts, advances the implementation of several causal inference approaches for environmental exposures and neurodevelopment. The first study investigated the molecular signatures associated with exposure to endocrine disrupting chemicals in childhood. The main innovation consisted in the integration of multi-omic data from a deeply characterized sub-sample of a large European cohort. The second study investigated how glucocorticosteroids might mediate the effects of exposure to endocrine disrupting chemicals on attentional function in childhood. Main innovations included the use of the meet-in-the-middle approach and of a formal causal inference technique: the parametric g-formula. The third study implemented an evidence triangulation approach to estimate causal effects of exposure to endocrine disrupting chemicals, including their mixtures, measured in pregnancy and childhood, on attentional function in adolescence. The main innovation consisted in the triangulation of evidence from several approaches to causal inference. This thesis thus enhances the implementation of formal causal inference and triangulation frameworks in the field of environmental epidemiology.<br />Universidad Pompeu Fabra. Doctorado en Biomedicina
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  Data: L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/
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RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 485
    Subjects:
      – SubjectFull: Disruptors endocrins
        Type: general
      – SubjectFull: Endocrine disruptors
        Type: general
      – SubjectFull: Disruptores endocrinos
        Type: general
      – SubjectFull: Cohort de naixements
        Type: general
      – SubjectFull: Birth cohort
        Type: general
      – SubjectFull: Cohorte de nacimiento
        Type: general
      – SubjectFull: Neurodesenvolupament
        Type: general
      – SubjectFull: Neurodevelopment
        Type: general
      – SubjectFull: Desarrollo neurológico
        Type: general
      – SubjectFull: Inferència causal
        Type: general
      – SubjectFull: Causal inference
        Type: general
      – SubjectFull: Inferencia causal
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      – SubjectFull: Multiòmica
        Type: general
      – SubjectFull: Multi-omics
        Type: general
      – SubjectFull: Multiómica
        Type: general
    Titles:
      – TitleFull: Early Life Exposure to Environmental Chemicals and Neurodevelopment through Childhood and Adolescence
        Type: main
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            NameFull: Fabbri, Lorenzo
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            – D: 19
              M: 12
              Type: published
              Y: 2025
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