Academic Journal
Effectiveness of regular oat β-glucan–enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial
| Title: | Effectiveness of regular oat β-glucan–enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial |
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| Authors: | Hjorth, Thérése, 1985, Schadow, Alena, Revheim, Ingrid, Spielau, Ulrike, Meyer, Klara, Rieder, Anne, Varela, Paula, Ballance, S., Koerner, Antje, Landberg, Rikard, 1981, Buyken, Anette, Dierkes, Jutta, Rosendahl-Riise, Hanne |
| Source: | EU-MARSS-5G The American journal of clinical nutrition. 122(3):724-732 |
| Subject Terms: | glycated hemoglobin (HbA1c), randomized controlled trial, glycemic control, β-glucans, type 2 diabetes, effectiveness trials |
| Description: | Background : A high intake of whole grains is associated with reduced risk of type 2 diabetes and cardiovascular disease, and soluble fiber from oats and barley, that is, β-glucans, has been shown to lower blood cholesterol and postprandial glycaemia. Despite such data and the European Food Safety Authority health claims supporting β-glucan–induced reductions in glucose and cholesterol, effectiveness in real-life settings among individuals at elevated risk of developing type 2 diabetes remains unclear. Objectives : This study aims to assess the long-term effectiveness of daily consumption of β-glucan–enriched bread, compared with whole-grain wheat bread, on glycated hemoglobin (HbA1c) and glycemic control in adults at risk of type 2 diabetes. Methods : A 16-wk randomized, double-blind dietary intervention was conducted in 194 adults [58 ± 8 y; BMI: 32 ± 5 kg/m 2 ; HbA1c 5.6% ± 0.3% (38 ± 3 mmol/mol); LDL cholesterol 3.6 ± 1.0 mmol/L] across sites in Germany, Norway, and Sweden. Participants consumed ≥3 slices/d of either β-glucan–enriched bread (6 g β-glucan/d) or control bread, 6 d/wk. Results : After 16 wk, there was no significant between-group difference in HbA1c [Δ = −0.01%, 95% confidence interval (CI): −0.03, 0.06; P = 0.49]. Similarly, no differences were observed in fasting glucose (Δ = −0.02 mmol/L; 95% CI: −0.11, 0.14), insulin (Δ = −0.76 pmol/L; 95% CI: −0.99, 2.5), or LDL cholesterol (Δ = −0.11 mmol/L; 95% CI: −0.27, 0.05) (all P > 0.05). Conclusions : Contrary to expectations from efficacy studies, this effectiveness trial does not support the metabolic benefits of oat-derived β-glucan–enriched bread under real-life conditions. A simple bread replacement may not be sufficient to improve glucose homeostasis in individuals at risk of type 2 diabetes. This trial was registered with clinicaltrials.gov as NCT04994327. |
| File Description: | electronic |
| Access URL: | https://research.chalmers.se/publication/547609 https://research.chalmers.se/publication/547609/file/547609_Fulltext.pdf |
| Database: | SwePub |
| ISSN: | 00029165 19383207 |
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| DOI: | 10.1016/j.ajcnut.2025.06.018 |