Academic Journal
The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment.
| Τίτλος: | The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment. |
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| Συγγραφείς: | Renaude, Elodie, Kroemer, Marie, Loyon, Romain, Binda, Delphine, Borg, Christophe, Guittaut, Michaël, Hervouet, Eric, Peixoto, Paul |
| Πηγή: | International Journal of Molecular Sciences, 21 (5), 1673 (2020-02-29) |
| Στοιχεία εκδότη: | MDPI, 2020. |
| Έτος έκδοσης: | 2020 |
| Θεματικοί όροι: | TIL, Th17 cells, epigenetic modifications, Cell Differentiation/immunology, Gene Expression Regulation, Neoplastic/genetics, Tumor Microenvironment/immunology, Cell Differentiation, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| Περιγραφή: | Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor RORγt and the production of IL-17. Epigenetic modifications such as post-translational histone modifications and DNA methylation play a key role in Th17 cell differentiation and high plasticity. Th17 cells are highly recruited in many types of cancer and can be associated with good or bad prognosis. Here, we will review the remodeling of the epigenome induced by the tumor microenvironment, which may explain Th17 cell predominance. We will also discuss the promising treatment perspectives of molecules targeting epigenetic enzymes to remodel a Th17-enriched tumor microenvironment. |
| Τύπος εγγράφου: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| Γλώσσα: | English |
| Relation: | https://www.mdpi.com/1422-0067/21/5/1673/pdf; urn:issn:1661-6596; urn:issn:1422-0067 |
| DOI: | 10.3390/ijms21051673 |
| Σύνδεσμος πρόσβασης: | https://orbi.uliege.be/handle/2268/330768 |
| Rights: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsorb.330768 |
| Βάση Δεδομένων: | ORBi |
| DOI: | 10.3390/ijms21051673 |
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