Mixed Materials
Unveiling the Thermodynamic Aspects of Drug-Cyclodextrin Interactions Through Isothermal Titration Calorimetry
| Τίτλος: | Unveiling the Thermodynamic Aspects of Drug-Cyclodextrin Interactions Through Isothermal Titration Calorimetry |
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| Additional Titles: | Due to their low toxicity and high aqueous solubility, cyclodextrins have emerged as a distinctive class of supramolecules with wide application in the pharmaceutical and food industry. Their ability to improve the water solubility, stability and pharmacokinetic profile of small molecules has established them as a rich toolkit for drug formulation. In order to improve the physicochemical characteristics and the pharmacokinetic profile of a drug through cyclodextrin inclusion, the proper cyclodextrin type has to be selected among the existing great variety consisting of both natural and synthetic variants. The selection of the most proper cyclodextrin variant comes after drug-cyclodextrin screening studies targeting the characterization of the complex formation and evaluation of the affinity and interaction forces participating in the complexation. Numerous analytical, spectroscopic, separation and electrochemical techniques have been applied to elucidate the interaction profile in a cyclodextrin-drug complex. Herein, we describe the application of Isothermal Titration Calorimetry (ITC) on cyclodextrin-drug complexes that enables the charting of the binding affinity and the thermodynamic profile of the inclusion complexes. We focus on the experimental design and present technical tips of the ITC application. To better illustrate the technique’s rationale, the interaction between 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and the antihypertensive drug losartan is investigated. © 2021, Springer Science+Business Media, LLC, part of Springer Nature. |
| Συγγραφείς: | Chatziathanasiadou, M.V., Mavromoustakos, T., Tzakos, A.G. |
| Στοιχεία εκδότη: | 2021 |
| Τύπος εγγράφου: | Mixed materials |
| Όροι ευρετηρίου: | scientific_publication_article, Scientific publication - Journal Article |
| Σύνδεσμος: | |
| Διαθεσιμότητα: | Open access content. Open access content Creative Commons Attribution-NonCommercial 4.0 (CC-BY-NC) |
| Σημείωση: | English |
| Other Numbers: | GRNKU oai:lib.uoa.gr:uoadl:3076685 uoadl:3076685 1478884826 |
| Πηγή συνεισφοράς: | NATIONAL & KAPODISTRIAN UNIV OF ATHENS From OAIster®, provided by the OCLC Cooperative. |
| Αριθμός Καταχώρησης: | edsoai.on1478884826 |
| Βάση Δεδομένων: | OAIster |
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