Mixed Materials
Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations
| Title: | Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations |
|---|---|
| Additional Titles: | Differential scanning calorimetry (DSC) is a widely utilized method for the interactions of drug molecules with drug delivery systems (DDSs). Herein is described a protocol for studying the interactions and entrapment efficiency of the prototype sartan losartan and the polydynamic, structurally similar irbesartan inside the nontoxic 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The thermal scan properties of both sartan molecules have been studied when physically mixed or complexed with the cyclodextrin. The thermograms indeed showed significant differences between the mixtures and complexes, establishing DSC as a valuable method to characterize the state of the drugs in these pharmaceutical formulations. © 2021, Springer Science+Business Media, LLC, part of Springer Nature. |
| Authors: | Naziris, N., Chountoulesi, M., Ntountaniotis, D., Mavromoustakos, T., Demetzos, C. |
| Publisher Information: | 2021 |
| Document Type: | Mixed materials |
| Index Terms: | scientific_publication_article, Scientific publication - Journal Article |
| URL: | |
| Availability: | Open access content. Open access content Creative Commons Attribution-NonCommercial 4.0 (CC-BY-NC) |
| Note: | English |
| Other Numbers: | GRNKU oai:lib.uoa.gr:uoadl:3077318 uoadl:3077318 1478876761 |
| Contributing Source: | NATIONAL & KAPODISTRIAN UNIV OF ATHENS From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: | edsoai.on1478876761 |
| Database: | OAIster |
| Description not available. |