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The Effects of Whole Body Gamma Irradiation on Mice, Age-Related Behavioral, and Pathophysiological Changes
| Title: | The Effects of Whole Body Gamma Irradiation on Mice, Age-Related Behavioral, and Pathophysiological Changes |
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| Additional Titles: | We designed a study with the objective to determine the long-term radiation effects of gamma rays, originating from a single shot of Co60 at a dose of 2 Gy on the 7-month-old male mice of the ICR line in 30 days after the irradiation. The aim of this study was to characterize the behavior of animals using the Open Field test, immuno-hematological status, and morpho-functional changes in the central nervous system of mice. Irradiated animals displayed significantly different behavior in the OF in comparison with the control group. The radiation damage was confirmed by assessing the ratio of leukocytes in the peripheral blood of mice at a later date after exposure to Co60. After irradiation, a decrease in the glioneuronal complex was observed in the irritated group as well as histological changes of brain cells. To sum up, not only was the hematological status of mice altered upon the total gamma irradiation, but also their behavior, which was most probably due to significant alterations in the CNS. Graphical Abstract: Study of influence of ionizing radiation on female mice, comparison between different age groups. Open Field test on the 30 days after 2 Gy of γ-rays and histological analysis indicated changes in behavioral patterns, leucocytes, and brain tissue. [Figure not available: see fulltext.] © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Authors: | Kolesnikova, I. A., Lalkovičova, M., Severyukhin, Yu. S., Golikova, K. N., Utina, D. M., Pronskikh, E. V., Despotović, Sanja Z., Gaevsky, V. N., Pirić, David, Masnikosa, Romana, Budennaya, N. N. |
| Source: | Cellular and Molecular Neurobiology |
| Publisher Information: | 2023 |
| Document Type: | Monograph |
| Index Terms: | Behavior, Gamma irradiation, Long-term effects, Neurodegeneration, Patho-morphology, article |
| Availability: | Open access content. Open access content ARR restrictedAccess |
| Note: | Cellular and Molecular Neurobiology English |
| Other Numbers: | RSPST oai:vinar.vin.bg.ac.rs:123456789/11224 0272-4340 https://vinar.vin.bg.ac.rs/handle/123456789/11224 001022457000001 10.1007/s10571-023-01381-1 2-s2.0-85163948641 1462374013 |
| Contributing Source: | UIVERSITY OF BELGRADE From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: | edsoai.on1462374013 |
| Database: | OAIster |
| Description not available. |