Mixed Materials
Vaccines for the control of cattle ticks in Uganda
| Τίτλος: | Vaccines for the control of cattle ticks in Uganda |
|---|---|
| Συγγραφείς: | Fuente, José de la, Contreras, Marinela, Ministerio de Economía, Industria y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España), National Agricultural Research Foundation, Junta de Comunidades de Castilla-La Mancha, Kasaija, Paul D. |
| Στοιχεία εκδότη: | CSIC-UCLM - Instituto de Investigación en Recursos Cinegéticos (IREC) 2023 |
| Τύπος εγγράφου: | Mixed materials |
| Περίληψη: | [Chapter I]: Ticks and tick-borne diseases have a negative impact on human and animal health worldwide. Ticks are the most important vectors of pathogen that cause economically important diseases in animals and affect human health and are widespread in Uganda due to the suitable climatic conditions. Traditional tick control methods are primarily based on the use of chemical acaricides, which can result in the selection of resistant ticks, environmental pollution, and contamination of milk and meat products with residues affecting in particular the cattle industry, resulting into economic losses. [General Introduction]: which describes the epidemiology of ticks and tick-borne diseases (TBDs) and their economic impact in Uganda. This chapter is a review paper [Kasaija, P.D., Estrada-Peña, A., Contreras, M., Kirunda, H., de la Fuente, J. (2021). Ticks and tick-borne diseases: a review of Uganda’s situation. Ticks and Tick-Borne Diseases 12, 101756] about how cattle are affected by TBDs. Due to the suitable climatic conditions, ticks are widespread in Uganda and cause over USD 1.1 billion of economics losses. Among the tick species in Uganda, the most economically important ticks are Rhipicephalus decoloratus, R. appendiculatus, and A. variegatum. In this country, exotic cattle breeds are more susceptible to ticks and the diseases they transmit than indigenous cattle, demanding intensive use of acaricides for tick control and prevention of TBDs. Consequently, the abusive use of these acaricides leads to the selection of acaricide-resistant tick populations. In this context, vaccination could be an effective alternative, that also integrated with tick control approaches that limit tick exposure, could disrupt the spread of ticks and TBDs. [Chapter II]: Design and evaluation of Subolesin-based vaccines for the control of cattle tick infestations in Uganda. Chapter I describes how vaccines are a feasible alternative to acaricide control of tick infestation in mammalian hosts. Immunization with recombinant SUB results in hosts (cattle) protection against infestation by decreasing tick survival and reproduction rates. The SUB protein sequences from the ticks R. decoloratus, R. appendiculatus, and A. variegatum from Uganda are highly homologous (75% amino acid identity), which explains the observed cross-protection [Kasaija, P.D., Contreras, M., Kabi, F., Mugerwa, S., de la Fuente, J. (2020). Vaccination with recombinant Subolesin antigens provides cross-tick species protection in Bos indicus and crossbred cattle in Uganda. Vaccines 8,319]. Cattle vaccination with SUB vaccine formulations induces sustained antigen-specific IgG production that affects various tick developmental stages with minor differences between tick species. The higher vaccine efficacy observed in crossbreed cattle reflects the influence of the host’s genotype on the immune response. Vaccination with a combination of SUB antigens from the different tick species produces limited vaccine efficacy. Nevertheless, study results suggest the possibility of using SUB-based antigens for the control of multiple tick species in different cattle breeds of Uganda. Additionally, in this chapter Quantum vaccinomics approach is used to identify B-cell reactive epitopes by mapping antigen peptides in a microarray using sera from vaccinated cattle. The reactive and conserved SUB peptides identified using epitope-mapping methods may have an influence on the vaccine efficacy and immunological protection observed and could thus constitute chimeric SUB antigens for production of cross-protective and personalised anti-tick vaccines [Contreras, M., Kasaija, P.D., Kabi, F., Mugerwa, S., de la Fuente, J. (2022). The correlation between Subolesin-reactive epitop [Chapter III]: Design and evaluation of oral vaccine formulations based on Subolesin and heat inactivated mycobacteria immunostimulant for the control of cattle tick infestations in Uganda.In this chapter includes and optimization of vaccine formulations, including the possibility of oral administration to improve cattle welfare and safety. Orally administered SUB vaccine formulations, such as SUB+IV, improved vaccine delivery and safety. The SUB+IV vaccine antigens activate both the innate and adaptive immune pathways which improves overall vaccine efficacy [Contreras, M., Kasaija, P.D., Merino, O., de la Cruz-Hernandez, N.I., Gortazar, C., de la Fuente, J. (2019). Oral vaccination with a formulation combining R. microplus Subolesin with heat inactivated Mycobacterium bovis reduces tick infestations in cattle. Frontiers in Cellular and Infection Microbiology 9, 45]. In a second study including in this chapter, oral R. decoloratus SUB with IV vaccine formulation showed good results for controlling tick infestations of R. appendiculatus and R. decoloratus [Kasaija, P.D., Contreras, M., Kabi, F., Mugerwa, S., Garrido, J.M., Gortazar, C., de la Fuente, J. (2022). Oral vaccine formulation combining tick Subolesin with heat inactivated mycobacteria provides control of cross-species cattle tick infestations. Vaccine 40,4564-4573]. [Chapter IV]: General discussion Chapter IV is presented as a general discussion with an overview of interventions and challenges for the control of ticks and tick-borne diseases in Uganda, being a priority for the Government of Uganda to promote economic growth in the country. A multidisciplinary approach to combining different control measures including cattle management and the rational use of acaricides and the development and application of anti-tick vaccines are proposed in this chapter. In addition, collaboration between research institutions specialized in these areas with those located in the affected countries is necessary to achieve these goals [de la Fuente, J., Contreras, M., Kasaija, P.D., Gortázar, C., Ruiz-Fons, J.F., Mateo, R., Kabi, F. (2019). Towards a multidisciplinary approach to improve cattle health and production in Uganda. Vaccines 7: 165]. As an example of these approaches and collaborations this chapter also includes a collaboration program that was established between the group of Health and Biotechnology (SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the National Agricultural Research Organization of Uganda (NARO) for the development of vaccines for the control of cattle ticks in Uganda. In this context, a controlled pen trials identified a tick protective antigen, R. appendiculatus SUB, and a cross-species-effective vaccine formulation was designed and exposed in this chapter [Kabi, F., Dhikusooka, M., Matovu, M., Mugerwa, S., Kasaija, P., Emudong, P., Kirunda, H., Contreras, M., Gortázar, C., de la Fuente, J. (2022). Monitoring the Subolesin vaccine field trial for safer control of cattle ticks amidst increasing acaricide resistance in Uganda. Vaccines 10: 1594]. |
| Όροι ευρετηρίου: | tesis doctoral |
| Σύνδεσμος: | Sí info:eu-repo/grantAgreement/MINECO//BFU2016-79892-P info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116761GB-I00/ES/IDENTIFICACION Y CARACTERIZACION DE BIOMOLECULAS EN LA SALIVA DE GARRAPATAS Y MECANISMOS ASOCIADOS CON LA RESPUESTA INMUNE FRENTE A ALPHA-GAL |
| Διαθεσιμότητα: | Open access content. Open access content closedAccess |
| Σημείωση: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/341103 1416003358 |
| Πηγή συνεισφοράς: | CSIC From OAIster®, provided by the OCLC Cooperative. |
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