Mixed Materials
Sensitivity and specificity considerations for fMRI encoding, decoding, and mapping of auditory cortex at ultra-high field
| Τίτλος: | Sensitivity and specificity considerations for fMRI encoding, decoding, and mapping of auditory cortex at ultra-high field |
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| Συγγραφείς: | De Martino, Federico, Kemper, Valentin G., Schmitter, Sebastian, Vu, A.T., Uğurbil, Kâmil, Formisano, Elia, Yacoub, Essa, Moerel, Michelle |
| Πηγή: | Neuroimage vol.164 (2018) date: 2018-01-01 p.18-31 [ISSN 1053-8119] |
| Στοιχεία εκδότη: | 2018 |
| Τύπος εγγράφου: | Mixed materials |
| Περίληψη: | Following rapid technological advances, ultra-high field functional MRI (fMRI) enables exploring correlates of neuronal population activity at an increasing spatial resolution. However, as the fMRI blood-oxygenation-level-dependent (BOLD) contrast is a vascular signal, the spatial specificity of fMRI data is ultimately determined by the characteristics of the underlying vasculature. At 7T, fMRI measurement parameters determine the relative contribution of the macro- and microvasculature to the acquired signal. Here we investigate how these parameters affect relevant high-end fMRI analyses such as encoding, decoding, and submillimeter mapping of voxel preferences in the human auditory cortex. Specifically, we compare a T2* weighted fMRI dataset, obtained with 2D gradient echo (GE) EPI, to a predominantly T2 weighted dataset obtained with 3D GRASE. We first investigated the decoding accuracy based on two encoding models that represented different hypotheses about auditory cortical processing. This encoding/decoding analysis profited from the large spatial coverage and sensitivity of the T2* weighted acquisitions, as evidenced by a significantly higher prediction accuracy in the GE-EPI dataset compared to the 3D GRASE dataset for both encoding models. The main disadvantage of the T2* weighted GE-EPI dataset for encoding/decoding analyses was that the prediction accuracy exhibited cortical depth dependent vascular biases. However, we propose that the comparison of prediction accuracy across the different encoding models may be used as a post processing technique to salvage the spatial interpretability of the GE-EPI cortical depth-dependent prediction accuracy. Second, we explored the mapping of voxel preferences. Large-scale maps of frequency preference (i.e., tonotopy) were similar across datasets, yet the GE-EPI dataset was preferable due to its larger spatial coverage and sensitivity. However, submillimeter tonotopy maps revealed biases in assigned frequency prefe |
| Όροι ευρετηρίου: | Algorithms, Auditory Cortex/diagnostic imaging, Brain Mapping/methods, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Sensitivity and Specificity, Article |
| Σύνδεσμος: | |
| Διαθεσιμότητα: | Open access content. Open access content |
| Σημείωση: | DOI: 10.1016/j.neuroimage.2017.03.063 English |
| Other Numbers: | NLMAT oai:cris.maastrichtuniversity.nl:publications/4dd6eaf6-5040-4c2c-a433-80b58d5ed300 https://cris.maastrichtuniversity.nl/en/publications/4dd6eaf6-5040-4c2c-a433-80b58d5ed300 1363312629 |
| Πηγή συνεισφοράς: | UNIVERSITEIT MAASTRICHT From OAIster®, provided by the OCLC Cooperative. |
| Αριθμός Καταχώρησης: | edsoai.on1363312629 |
| Βάση Δεδομένων: | OAIster |
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