Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
The ERG1 K+ Channel and Its Role in Neuronal Health and Disease |
| Συγγραφείς: |
Francisco G. Sanchez-Conde, Eric N. Jimenez-Vazquez, David S. Auerbach, David K. Jones |
| Πηγή: |
Frontiers in Molecular Neuroscience, Vol 15 (2022) |
| Στοιχεία εκδότη: |
Frontiers Media S.A., 2022. |
| Έτος έκδοσης: |
2022 |
| Συλλογή: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Θεματικοί όροι: |
ERG1, KCNH2, Kv11.1, epilepsy, brain, electrophysiology, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| Περιγραφή: |
The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1’s relationship to the mammalian brain and highlights key questions that have yet to be answered. |
| Τύπος εγγράφου: |
article |
| Περιγραφή αρχείου: |
electronic resource |
| Γλώσσα: |
English |
| ISSN: |
1662-5099 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnmol.2022.890368/full; https://doaj.org/toc/1662-5099 |
| DOI: |
10.3389/fnmol.2022.890368 |
| Σύνδεσμος πρόσβασης: |
https://doaj.org/article/f781e34a461b436cba5f92c403c556ee |
| Αριθμός Καταχώρησης: |
edsdoj.f781e34a461b436cba5f92c403c556ee |
| Βάση Δεδομένων: |
Directory of Open Access Journals |