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Yao Zhang,* Xulin Chen,* Shiqin Xu, Shanwu Feng, Caijuan Li Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Caijuan Li, Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China, Tel +8617372283502, Email lcj_1228@njmu.edu.cn Shanwu Feng, Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China, Tel +8613921426351, Email shanwufeng@163.comPurpose: The purpose of this research was to investigate whether intravenous low dose of butorphanol (1mg) at the onset of epidural analgesia (EA) can reduce the incidence of ERMF during labor.Patients and Methods: Four hundred and twenty-four women, aged 18 to 40 years, BMI 0.05). In addition, mild dizziness related to butrophanol was only appeared in few subjects in the first 2 hours after EA (P< 0.05). No severe maternal or neonatal adverse effects were observed in all subjects.Conclusion: A low dose of butorphanol intravenously used at the onset of EA in women undergoing vaginal delivery could effectively reduce the incidence of ERMF. Butorphanol may serve as a potential intervention for preventing ERMF in future.Keywords: butorphanol, ERMF, EA, maternal temperature, vaginal delivery |