Bibliographic Details
| Title: |
Analysis of operability parameter changes in neoadjuvant treatment with chemotherapy and anti-PD-1/PD-L1 |
| Authors: |
M Sereno, A Collazo-Lorduy, Y Garitaonaindia, D Gómez de Antonio, J Baena Espinar, C Aguado de la Rosa, P Cruz Castellanos, S Falagán Martínez, LE Chara Valverde, R López-Castro, A López-Martin, J Rubio-Pérez, A Gómez Rueda, C Traseira Puchol, X Mielgo Rubio, B Losada Vila, J Rogado, E Bernal Hertfelder, L Gutiérrez Sainz, JL Campo-Cañaveral, I Romano, I. Thuissard, G Rubio Romero, E Casado Sáenz |
| Source: |
Cancer Treatment and Research Communications, Vol 43, Iss , Pp 100910- (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Neoadjuvant, Operability, DLCO, Chemo-inmunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| Description: |
Background: The adoption of combined chemotherapy (CT) and immunotherapy (IO) has advanced neoadjuvant therapy (NA) for non-small cell lung cancer (NSCLC), but data on functional impacts are limited. This multicenter retrospective study evaluates respiratory function in NSCLC patients undergoing NA. Methods: From 2020 to 2024, 186 patients treated with CT or CT-IO (anti-PD-1/PD-L1) were analyzed. Respiratory tests (DLCO, FEV1, FVC) pre- and post-NA were compared, alongside clinical, pathological, and surgical variables. Results: Median age: 68; 66.6 % male; 93 % smokers/ex-smokers, histologies: Squamous and adenocarcinoma (46 % each), DLCO decline was greater in CT-IO vs. CT (-12.6 % vs. -7.8 %, p = 0.007) and CT-IO showed increased FEV1 (+3.8 % vs. -2.5 %, p = 0.001) and FVC (+3.7 % vs. -0.7 %, p = 0.003), surgery rate: 85.7 % (lobectomy most common at 83.3 %) and no differences in complications were found except for 9 immune-mediated events in CT-IO. Conclusions: CT-IO impacts DLCO more but improves FEV1 and FVC compared to CT. These findings warrant further validation in prospective studies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2468-2942 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2468294225000474; https://doaj.org/toc/2468-2942 |
| DOI: |
10.1016/j.ctarc.2025.100910 |
| Access URL: |
https://doaj.org/article/f0c2073ab0a24ddfa87db2c03013c1b2 |
| Accession Number: |
edsdoj.f0c2073ab0a24ddfa87db2c03013c1b2 |
| Database: |
Directory of Open Access Journals |