Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
| Συγγραφείς: |
Tjark Ortgies, Michael Rullmann, Dorothée Ziegelhöfer, Annett Bläser, Ulrich H. Thome |
| Πηγή: |
BMC Pediatrics, Vol 21, Iss 1, Pp 1-13 (2021) |
| Στοιχεία εκδότη: |
BMC, 2021. |
| Έτος έκδοσης: |
2021 |
| Συλλογή: |
LCC:Pediatrics |
| Θεματικοί όροι: |
Early-onset-Sepsis, Neurodevelopment, Preterm, VLBW, Pediatrics, RJ1-570 |
| Περιγραφή: |
Abstract Aims The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in very low birth weight infants. Methods This was a single-center cohort study on infants weighing less than 1500 g with a gestational age below 35 weeks at birth born between 2008 and 2011. Neurodevelopmental outcomes were assessed at follow-up with the Bayley Scales of Infant Development-II. EOS was defined as either culture-proven EOS or clinical EOS using blood culture, CrP levels, and clinical symptoms and treatment. Neurodevelopmental impairment (NDI) was defined as one or more of the following: Mental Developmental Index (MDI) and/or Psychomotor Developmental Index (PDI) scores lower than 70; presence of cerebral palsy. Results Of 405 eligible newborns in the study period 166 were included. Two had culture-proven and 29 clinical EOS. Median MDI scores in patients with EOS were 96 (IQR: 86–106) and in the control group 94 (84–106, p = 0.77). PDI scores in patients with EOS were 96 (86–106) and in the control group 99,5 (92–103, p = 0.03). Of infected patients 7/31 (24%) showed NDI as defined, whereas only 11/135 (8%) showed NDI in the control group (OR 3.3, p = 0.03). Multiple regression analyses identified chorioamnionitis and poor CRIB-Scores as individual risk factors for MDI or PDI values |
| Τύπος εγγράφου: |
article |
| Περιγραφή αρχείου: |
electronic resource |
| Γλώσσα: |
English |
| ISSN: |
1471-2431 |
| Relation: |
https://doaj.org/toc/1471-2431 |
| DOI: |
10.1186/s12887-021-02738-5 |
| Σύνδεσμος πρόσβασης: |
https://doaj.org/article/f014daa1c53843ca801a3ecb977b01e4 |
| Αριθμός Καταχώρησης: |
edsdoj.f014daa1c53843ca801a3ecb977b01e4 |
| Βάση Δεδομένων: |
Directory of Open Access Journals |