Bibliographic Details
| Title: |
Hypophosphataemia risk associated with ferric carboxymaltose in heart failure: A pooled analysis of clinical trials |
| Authors: |
Giuseppe MC Rosano, Kamyar Kalantar‐Zadeh, Ewa A. Jankowska |
| Source: |
ESC Heart Failure, Vol 10, Iss 2, Pp 1294-1304 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Hypophosphataemia, Ferric carboxymaltose, Heart failure, Intravenous, Chronic kidney disease, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| Description: |
Abstract Aims Iron deficiency is a common finding among patients with heart failure (HF) and is associated with adverse outcomes, including decreased quality of life, increased risk of hospitalization, and decreased survival. Intravenous ferric carboxymaltose (FCM) has been shown to improve outcomes among patients with HF and concomitant iron deficiency, but FCM is associated with an increased risk of hypophosphataemia. We aimed to better characterize this risk among HF populations. Methods and results This pooled analysis examined data from 41 studies of adults with iron deficiency across disease states and therapeutic areas. Among the 7931 patients treated with FCM available for analysis, 14% made up the HF subgroup. Additional subgroups included women's health (36%), non–dialysis‐dependent chronic kidney disease (NDD‐CKD; 27%), haemodialysis‐dependent chronic kidney disease (HD‐CKD; 1%), gastrointestinal (10%), neurology (3%), and other (10%). The incidence of post‐baseline moderate or severe hypophosphataemia (i.e. serum phosphate [PO43−] level 60 mL/min/1.73 m2 vs. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.14286 |
| Access URL: |
https://doaj.org/article/9c503788dd1847b79fbd01eb5d2d8a2e |
| Accession Number: |
edsdoj.9c503788dd1847b79fbd01eb5d2d8a2e |
| Database: |
Directory of Open Access Journals |