Academic Journal
The Prognostic Value of Baseline PSA Density on Long-term Oncological Outcomes in Men with an Initial Negative Prostate Biopsy: Results from ERSPC Rotterdam
| Title: | The Prognostic Value of Baseline PSA Density on Long-term Oncological Outcomes in Men with an Initial Negative Prostate Biopsy: Results from ERSPC Rotterdam |
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| Authors: | Meike J. van Harten, Sebastiaan Remmers, Ivo I. de Vos, Lionne D.F. Venderbos, Roderick C.N. van den Bergh, Monique J. Roobol, F.H. Schroder, W.J. Kirkels, J.B.W Rietbergen, I.W. Koeter, R. Raaijmakers, S.H. de Vries, S. Roemeling, C. Gosselaar, T. Wolters, R.C.N. van den Bergh, P.J. van Leeuwen, M. Bul, X. Zhu, L.P. Bokhorst, A.R.Alberts, F-J. Drost, J.F.M. Verbeek, D.F. Osses, H.B. Luiting, R. Hogenhout, I.I. de Vos, R.C.A. Leenen, J.J. Lodder, M.J. van Harten, S.F. Westerhout, F. Denijs, E.F.H. Mulder, L.D.F. Venderbos, K. Beyer, H.A. van Vugt, G. Yurdakul, A. Boeken-Kruger, C. Wijburg, M. Forouzanfor, M. de Boer, R. Postma, A.N. Vis, Th van der Kwast, R. Hoedemaeker, G.J.L.H. van Leenders, R. van Schaik, P.J. van der Maas, H.J. De Koning, E.A. Heijnsdijk, S. Otto, G. Draisma, P. Beemsterboer, I. Korfage, R. Boer, M. Wildhagen, D. Nieboer, W. Merkelbach, W. Hoekstra, J. Blom, T. Lock, A. Noordzij, RAM Damhuis, A. Reedijk, R. Kranse, J. Helleman, D.W. Roobol, W. Roobol, E. van den Berg, G-J de Zwart, C.G.A.M. Franken-Raab, M. van Slooten-Midderigh, A. Smit, V van der Drift, E. de Bilde, Mden Rooijen, L. Mani, M. Visser-van Dongen, H. Versteeg-Leenheer, B. Zoutendijk, H. van Meurs, A.E. de Bruijn |
| Source: | European Urology Open Science, Vol 90, Iss , Pp 131-136 (2026) |
| Publisher Information: | Elsevier, 2026. |
| Publication Year: | 2026 |
| Collection: | LCC:Diseases of the genitourinary system. Urology LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Prostate cancer, Screening, Negative biopsy, PSA density, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| Description: | Introduction: Baseline prostate-specific antigen (PSA) is associated with the risk of metastatic disease (M+) and prostate cancer (PCa)-specific mortality (PCSM). However, the prognostic value of baseline PSA density (PSA-D) for long-term oncological outcomes is less well established. This study aims to evaluate the prognostic value of baseline PSA-D for oncological outcomes in men who participated in a population-based screening study and had an elevated PSA but a negative prostate biopsy at their first screening visit. Material and methods: Data from the Rotterdam cohort of the European Randomized Study of Screening for Prostate Cancer (ERSPC) were used. All men aged 55–69 yr with PSA ≥ 3 ng/ml following a negative (sextant) biopsy at initial screening were included. Screening was repeated every 4 yr, with (repeat) biopsy if PSA ≥ 3 ng/ml. Screen–detected PCa was defined as PCa diagnosed during scheduled screening rounds. Men were stratified into three age groups according to the maximum number of potential screening rounds: 55–59, 60–64, and 65–69, and three baseline PSA-D groups reflecting clinical practice: |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2666-1683 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666168326006373; https://doaj.org/toc/2666-1683 |
| DOI: | 10.1016/j.euros.2026.06.006 |
| Access URL: | https://doaj.org/article/5455016f4ce1428c88264a816fd11d61 |
| Accession Number: | edsdoj.5455016f4ce1428c88264a816fd11d61 |
| Database: | Directory of Open Access Journals |
| ISSN: | 26661683 |
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| DOI: | 10.1016/j.euros.2026.06.006 |