Academic Journal
PO:30:151 | Clinical characteristics and evolution of juvenile undifferentiated connective tissue diseases: results of a single-center study
| Title: | PO:30:151 | Clinical characteristics and evolution of juvenile undifferentiated connective tissue diseases: results of a single-center study |
|---|---|
| Authors: | Società Italiana di Reumatologia |
| Source: | Reumatismo, Vol 77, Iss s1 (2025) |
| Publisher Information: | PAGEPress Publications, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Internal medicine |
| Subject Terms: | UCTD, Connective tissue diseases, Juvenile, Medicine, Internal medicine, RC31-1245 |
| Description: | Background. Juvenile undifferentiated connective tissue diseases (UCTD) represent a heterogeneous clinical entity characterized by symptoms suggestive of connective tissue disease without meeting the classification criteria. Currently, epidemiological and prognostic knowledge about the pediatric population is limited, with implications for clinical and therapeutic management. The aim of our work is to describe the clinical and serological characteristics of a single-center cohort of patients with juvenile UCTD, evaluating the clinical course and potential evolution toward defined connective tissue diseases. Materials and Methods. We conducted a retrospective study on 33 patients diagnosed with juvenile UCTD who were followed at our center from 2006 to 2025. Inclusion criteria: age 16 years or less at onset, disease duration of at least 12 months, at least one clinical sign suggestive of connective tissue disease, and positivity in at least two ANA or ENA tests. Demographic, clinical, serological, capillaroscopic, and therapeutic data were collected. Results. The demographic and clinical characteristics are shown in Table 1. All patients tested positive for ANA. In 7 patients, ANA negativity was observed at a mean follow-up of 12 months, associated with lower ESR values (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Italian |
| ISSN: | 0048-7449 2240-2683 |
| Relation: | https://www.reumatismo.org/reuma/article/view/2069; https://doaj.org/toc/0048-7449; https://doaj.org/toc/2240-2683 |
| Access URL: | https://doaj.org/article/4f895e93cd8a4a2f86e000b29f7b96cf |
| Accession Number: | edsdoj.4f895e93cd8a4a2f86e000b29f7b96cf |
| Database: | Directory of Open Access Journals |
| ISSN: | 00487449 22402683 |
|---|