Transcriptomic profile of cationic channels in human pulmonary arterial hypertension

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
Συγγραφείς:	Francisco Perez-Vizcaino, Angel Cogolludo, Gema Mondejar-Parreño
Πηγή:	Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Στοιχεία εκδότη:	Nature Portfolio, 2021.
Έτος έκδοσης:	2021
Συλλογή:	LCC:Medicine LCC:Science
Θεματικοί όροι:	Medicine, Science
Περιγραφή:	Abstract The dysregulation of K+ channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (83%). The principal component analysis indicated that dysregulated cationic channel expression is a signature of the disease. Changes were very similar in idiopathic, connective tissue disease and congenital heart disease associated PAH. This analysis 1) is in agreement with the widely recognized pathophysiological role of TASK1 and KV1.5, 2) supports previous preliminary reports pointing to the dysregulation of several K+ channels including the downregulation of KV1.1, KV1.4, KV1.6, KV7.1, KV7.4, KV9.3 and TWIK2 and the upregulation of KCa1.1 and 3) points to other cationic channels dysregulated such as Kv7.3, TALK2, CaV1 and TRPV4 which might play a pathophysiological role in PAH. The significance of other changes found in Na+ and TRP channels remains to be investigated.
Τύπος εγγράφου:	article
Περιγραφή αρχείου:	electronic resource
Γλώσσα:	English
ISSN:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-021-95196-z
Σύνδεσμος πρόσβασης:	https://doaj.org/article/40c07f33681c45b986b8384fe5b327e7
Αριθμός Καταχώρησης:	edsdoj.40c07f33681c45b986b8384fe5b327e7
Βάση Δεδομένων:	Directory of Open Access Journals

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Περιγραφή
ISSN:	20452322
DOI:	10.1038/s41598-021-95196-z