Academic Journal
Coagulation dysfunction in children with secondary hemophagocytic lymphohistiocytosis: a comprehensive analysis
| Title: | Coagulation dysfunction in children with secondary hemophagocytic lymphohistiocytosis: a comprehensive analysis |
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| Authors: | Chaojun Duan, Qing Liao, Jiale Gong, Xiaofang Bai, Xiangdong Xu, Bo Zhang |
| Source: | Annals of Medicine, Vol 58, Iss 1 (2026) |
| Publisher Information: | Taylor & Francis Group, 2026. |
| Publication Year: | 2026 |
| Collection: | LCC:Medicine |
| Subject Terms: | Haemophagocytic lymphohistiocytosis, children, prognosis, coagulation function, disseminated intravascular coagulation, Medicine |
| Description: | Objective Coagulation dysfunction plays a critical role in the pathogenesis and prognosis of secondary haemophagocytic lymphohistiocytosis (sHLH) in children. This study aims to systematically analyze the coagulation profiles in paediatric sHLH patients, evaluate their prognostic value and provide an effective basis for reducing mortality in children with HLH.Methods A total of 209 paediatric patients with sHLH were enrolled in this study. Coagulation parameters at admission were collected and compared across groups stratified by aetiology, prognosis and presence of disseminated intravascular coagulation (DIC). The dynamic evolution of coagulation parameters was analyzed using LOWESS curve fitting. LASSO regression was applied to screen for potential risk factors for DIC in sHLH patients, followed by univariate and multivariate logistic regression to identify independent risk factors. Similarly, Kaplan–Meier survival analysis along with univariate and multivariate logistic regression models were used to determine independent risk factors associated with prognosis in sHLH patients.Results Paediatric patients with secondary haemophagocytic lymphohistiocytosis (sHLH) presented with significant coagulation abnormalities upon hospital admission, as evidenced by markedly elevated prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), thrombin time (TT) and D-dimer (DD) levels (all p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1365-2060 0785-3890 |
| Relation: | https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060 |
| DOI: | 10.1080/07853890.2026.2617724 |
| Access URL: | https://doaj.org/article/32ae457040384391b68d90a76fb476a1 |
| Accession Number: | edsdoj.32ae457040384391b68d90a76fb476a1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 13652060 07853890 |
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| DOI: | 10.1080/07853890.2026.2617724 |