Academic Journal
Effects of ginsenoside Rg1 on proliferation, migration and inflammatory cytokine expression in human gingival fibroblasts
| Τίτλος: | Effects of ginsenoside Rg1 on proliferation, migration and inflammatory cytokine expression in human gingival fibroblasts |
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| Συγγραφείς: | CAO Qian, YUAN Changyong, ZHOU Yao, LI Xiaofei, ZHU Shaoyue, WANG Penglai |
| Πηγή: | Kouqiang yixue, Vol 45, Iss 11, Pp 844-848 (2025) |
| Στοιχεία εκδότη: | Editorial Office of Stomatology, 2025. |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | LCC:Dentistry LCC:Other systems of medicine |
| Θεματικοί όροι: | human gingival fibroblasts, ginsenoside rg1, cell proliferation, cell migration, inflammation, Dentistry, RK1-715, Other systems of medicine, RZ201-999 |
| Περιγραφή: | Objective To investigate the effects and molecular mechanisms of ginsenoside Rg1 (GSRG1) on the proliferation, migration, and inflammatory cytokine expression of human gingival fibroblasts (HGFs) induced by lipopolysaccharide (LPS). Methods HGFs were isolated and cultured using the tissue block method. The effects of different concentrations of LPS (0, 1, 5, 10, 20 μg/mL) on inflammatory cytokines in HGFs were detected by ELISA. Cells were divided into three groups: control group (no treatment), LPS group (20 μg/mL LPS), and LPS+GSRG1 group (20 μg/mL LPS and 100 mg/L GSRG1). Cell proliferation was detected by cell counting kit-8 (CCK-8); cell migration was assessed by Transwell assay; intracellular reactive oxygen species (ROS) levels were compared using flow cytometry; and the expression levels of TNF-α, IL-6, NLRP3, p-p38, and p38 proteins were detected by Western blot. Results LPS concentrations of 5, 10, and 20 μg/mL significantly increased the expression of IL-6 and TNF-α in HGFs (P |
| Τύπος εγγράφου: | article |
| Περιγραφή αρχείου: | electronic resource |
| Γλώσσα: | Chinese |
| ISSN: | 1003-9872 |
| Relation: | https://www.stomatology.cn/fileup/1003-9872/PDF/1763449291417-1084890722.pdf; https://doaj.org/toc/1003-9872 |
| DOI: | 10.13591/j.cnki.kqyx.2025.11.008 |
| Σύνδεσμος πρόσβασης: | https://doaj.org/article/180ed4251e074c33ab73aa4d4fbbace6 |
| Αριθμός Καταχώρησης: | edsdoj.180ed4251e074c33ab73aa4d4fbbace6 |
| Βάση Δεδομένων: | Directory of Open Access Journals |
| ISSN: | 10039872 |
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| DOI: | 10.13591/j.cnki.kqyx.2025.11.008 |