Academic Journal
A genome-wide association study of total child psychiatric problems scores.
| Τίτλος: | A genome-wide association study of total child psychiatric problems scores. |
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| Συγγραφείς: | Neumann, A, Nolte, IM, Pappa, I, Ahluwalia, TS, Pettersson, E, Rodriguez, A, Whitehouse, A, Van Beijsterveldt, CEM, Benyamin, B, Hammerschlag, AR, Helmer, Q, Karhunen, V, Krapohl, E, Lu, Y, Van der Most, PJ, Palviainen, T, St Pourcain, B, Seppälä, I, Suarez, A, Vilor-Tejedor, N, Tiesler, CMT, Wang, C, Wills, A, Zhou, A, Alemany, S, Bisgaard, H, Bønnelykke, K, Davies, GE, Hakulinen, C, Henders, AK, Hyppönen, E, Stokholm, J, Bartels, M, Hottenga, J-J, Heinrich, J, Hewitt, J, Keltikangas-Järvinen, L, Korhonen, T, Kaprio, J, Lahti, J, Lahti-Pulkkinen, M, Lehtimäki, T, Middeldorp, CM, Najman, JM, Pennell, C, Power, C, Oldehinkel, AJ, Plomin, R, Räikkönen, K, Raitakari, OT, Rimfeld, K, Sass, L, Snieder, H, Standl, M, Sunyer, J, Williams, GM, Bakermans-Kranenburg, MJ, Boomsma, DI, Van IJzendoorn, MH, Hartman, CA, Tiemeier, H |
| Πηγή: | 23 ; 1 |
| Στοιχεία εκδότη: | Public Library of Science (PLoS) |
| Έτος έκδοσης: | 2022 |
| Συλλογή: | Imperial College London: Spiral |
| Θεματικοί όροι: | Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, General Science & Technology |
| Θέμα γεωγραφικό: | United States |
| Περιγραφή: | Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | PLoS One; http://hdl.handle.net/10044/1/99340 |
| DOI: | 10.1371/journal.pone.0273116 |
| Διαθεσιμότητα: | http://hdl.handle.net/10044/1/99340 https://doi.org/10.1371/journal.pone.0273116 |
| Rights: | © 2022 Neumann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; http://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.FA210D0 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1371/journal.pone.0273116 |
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