Academic Journal
Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women.
| Τίτλος: | Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women. |
|---|---|
| Συγγραφείς: | Perciani, CT, Sekhon, M, Hundal, S, Farah, B, Ostrowski, MA, Anzala, AO, McKinnon, LR, Jaoko, W, MacDonald, KS |
| Στοιχεία εκδότη: | Oxford Academic |
| Έτος έκδοσης: | 2018 |
| Συλλογή: | University of Nairobi Digital Repository |
| Περιγραφή: | BACKGROUND: Attenuated varicella zoster virus (VZV) is a promising vector for recombinant vaccines. Because human immunodeficiencyvirus (HIV) vaccines are believed to require mucosal immunogenicity, we characterized mucosal VZV-specific humoral immunity following VZVOka vaccination. METHODS: Adult Kenyan VZV-seropositive women (n = 44) received a single dose of the live zoster VZVOka vaccine. The anamnestic responses to the virus were followed longitudinally in both plasma and mucosal secretions using an in-house glycoprotein enzyme-linked immunosorbent assay and safety and reactogenicity monitored. VZV seroprevalence and baseline responses to the virus were also characterized in our cohorts (n = 288). RESULTS: Besides boosting anti-VZV antibody responses systemically, vaccination also boosted anti-VZV immunity in the cervicovaginal mucosa with a 2.9-fold rise in immunoglobulin G (P < .0001) and 1.6-fold rise in immunoglobulin A (IgA) (P = .004) from the time before immunization and 4 weeks postvaccination. Baseline analysis demonstrated high avidity antibodies at the gastrointestinal and genital mucosa of VZV-seropositive women. Measurement of VZV-specific IgA in saliva is a sensitive tool for detecting prior VZV infection. CONCLUSIONS: VZVOka vaccine was safe and immunogenic in VZV-seropositive adult Kenyan women. We provided compelling evidence of VZV ability to induce genital mucosa immunity. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://www.ncbi.nlm.nih.gov/pubmed/29800309; http://erepository.uonbi.ac.ke/handle/11295/106535 |
| Διαθεσιμότητα: | https://www.ncbi.nlm.nih.gov/pubmed/29800309 http://erepository.uonbi.ac.ke/handle/11295/106535 |
| Αριθμός Καταχώρησης: | edsbas.F60AC681 |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://www.ncbi.nlm.nih.gov/pubmed/29800309# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| Items | – Name: Title Label: Title Group: Ti Data: Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Perciani%2C+CT%22">Perciani, CT</searchLink><br /><searchLink fieldCode="AR" term="%22Sekhon%2C+M%22">Sekhon, M</searchLink><br /><searchLink fieldCode="AR" term="%22Hundal%2C+S%22">Hundal, S</searchLink><br /><searchLink fieldCode="AR" term="%22Farah%2C+B%22">Farah, B</searchLink><br /><searchLink fieldCode="AR" term="%22Ostrowski%2C+MA%22">Ostrowski, MA</searchLink><br /><searchLink fieldCode="AR" term="%22Anzala%2C+AO%22">Anzala, AO</searchLink><br /><searchLink fieldCode="AR" term="%22McKinnon%2C+LR%22">McKinnon, LR</searchLink><br /><searchLink fieldCode="AR" term="%22Jaoko%2C+W%22">Jaoko, W</searchLink><br /><searchLink fieldCode="AR" term="%22MacDonald%2C+KS%22">MacDonald, KS</searchLink> – Name: Publisher Label: Publisher Information Group: PubInfo Data: Oxford Academic – Name: DatePubCY Label: Publication Year Group: Date Data: 2018 – Name: Subset Label: Collection Group: HoldingsInfo Data: University of Nairobi Digital Repository – Name: Abstract Label: Description Group: Ab Data: BACKGROUND: Attenuated varicella zoster virus (VZV) is a promising vector for recombinant vaccines. Because human immunodeficiencyvirus (HIV) vaccines are believed to require mucosal immunogenicity, we characterized mucosal VZV-specific humoral immunity following VZVOka vaccination. METHODS: Adult Kenyan VZV-seropositive women (n = 44) received a single dose of the live zoster VZVOka vaccine. The anamnestic responses to the virus were followed longitudinally in both plasma and mucosal secretions using an in-house glycoprotein enzyme-linked immunosorbent assay and safety and reactogenicity monitored. VZV seroprevalence and baseline responses to the virus were also characterized in our cohorts (n = 288). RESULTS: Besides boosting anti-VZV antibody responses systemically, vaccination also boosted anti-VZV immunity in the cervicovaginal mucosa with a 2.9-fold rise in immunoglobulin G (P < .0001) and 1.6-fold rise in immunoglobulin A (IgA) (P = .004) from the time before immunization and 4 weeks postvaccination. Baseline analysis demonstrated high avidity antibodies at the gastrointestinal and genital mucosa of VZV-seropositive women. Measurement of VZV-specific IgA in saliva is a sensitive tool for detecting prior VZV infection. CONCLUSIONS: VZVOka vaccine was safe and immunogenic in VZV-seropositive adult Kenyan women. We provided compelling evidence of VZV ability to induce genital mucosa immunity. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://www.ncbi.nlm.nih.gov/pubmed/29800309; http://erepository.uonbi.ac.ke/handle/11295/106535 – Name: URL Label: Availability Group: URL Data: https://www.ncbi.nlm.nih.gov/pubmed/29800309<br />http://erepository.uonbi.ac.ke/handle/11295/106535 – Name: AN Label: Accession Number Group: ID Data: edsbas.F60AC681 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.F60AC681 |
| RecordInfo | BibRecord: BibEntity: Languages: – Text: English Titles: – TitleFull: Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Perciani, CT – PersonEntity: Name: NameFull: Sekhon, M – PersonEntity: Name: NameFull: Hundal, S – PersonEntity: Name: NameFull: Farah, B – PersonEntity: Name: NameFull: Ostrowski, MA – PersonEntity: Name: NameFull: Anzala, AO – PersonEntity: Name: NameFull: McKinnon, LR – PersonEntity: Name: NameFull: Jaoko, W – PersonEntity: Name: NameFull: MacDonald, KS IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2018 Identifiers: – Type: issn-locals Value: edsbas |
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