Academic Journal
Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women.
| Τίτλος: | Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women. |
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| Συγγραφείς: | Perciani, CT, Sekhon, M, Hundal, S, Farah, B, Ostrowski, MA, Anzala, AO, McKinnon, LR, Jaoko, W, MacDonald, KS |
| Στοιχεία εκδότη: | Oxford Academic |
| Έτος έκδοσης: | 2018 |
| Συλλογή: | University of Nairobi Digital Repository |
| Περιγραφή: | BACKGROUND: Attenuated varicella zoster virus (VZV) is a promising vector for recombinant vaccines. Because human immunodeficiencyvirus (HIV) vaccines are believed to require mucosal immunogenicity, we characterized mucosal VZV-specific humoral immunity following VZVOka vaccination. METHODS: Adult Kenyan VZV-seropositive women (n = 44) received a single dose of the live zoster VZVOka vaccine. The anamnestic responses to the virus were followed longitudinally in both plasma and mucosal secretions using an in-house glycoprotein enzyme-linked immunosorbent assay and safety and reactogenicity monitored. VZV seroprevalence and baseline responses to the virus were also characterized in our cohorts (n = 288). RESULTS: Besides boosting anti-VZV antibody responses systemically, vaccination also boosted anti-VZV immunity in the cervicovaginal mucosa with a 2.9-fold rise in immunoglobulin G (P < .0001) and 1.6-fold rise in immunoglobulin A (IgA) (P = .004) from the time before immunization and 4 weeks postvaccination. Baseline analysis demonstrated high avidity antibodies at the gastrointestinal and genital mucosa of VZV-seropositive women. Measurement of VZV-specific IgA in saliva is a sensitive tool for detecting prior VZV infection. CONCLUSIONS: VZVOka vaccine was safe and immunogenic in VZV-seropositive adult Kenyan women. We provided compelling evidence of VZV ability to induce genital mucosa immunity. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://www.ncbi.nlm.nih.gov/pubmed/29800309; http://erepository.uonbi.ac.ke/handle/11295/106535 |
| Διαθεσιμότητα: | https://www.ncbi.nlm.nih.gov/pubmed/29800309 http://erepository.uonbi.ac.ke/handle/11295/106535 |
| Αριθμός Καταχώρησης: | edsbas.F60AC681 |
| Βάση Δεδομένων: | BASE |
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