Academic Journal
Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients
| Τίτλος: | Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients |
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| Συγγραφείς: | Müller, Markus, Brunner, Martin, Hollenstein, Ursula, Joukhadar, Christian, Schmid, Rainer, Minar, Erich, Ehringer, Herbert, Eichler, Hans Georg |
| Πηγή: | Antimicrobial Agents and Chemotherapy ; volume 43, issue 8, page 2056-2058 ; ISSN 0066-4804 1098-6596 |
| Στοιχεία εκδότη: | American Society for Microbiology |
| Έτος έκδοσης: | 1999 |
| Περιγραφή: | Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0.2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curve infection /area under the concentration-time curve unaffected tissue = 0.99 ± 0.15 [mean ± standard error], n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1128/aac.43.8.2056 |
| DOI: | 10.1128/AAC.43.8.2056 |
| Διαθεσιμότητα: | https://doi.org/10.1128/aac.43.8.2056 https://journals.asm.org/doi/pdf/10.1128/AAC.43.8.2056 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| Αριθμός Καταχώρησης: | edsbas.F2CF0B15 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1128/aac.43.8.2056 |
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