Academic Journal
Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants
| Τίτλος: | Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants |
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| Συγγραφείς: | Kwakkenbos, Linda, Levis, Brooke, Henry, Richard S, Virgili-Gervais, Gabrielle, Carrier, Marie-Eve, Bartlett, S. J., Gietzen, A., Gottesman, K., Guillot, G., Lawrie-Jones, A., Hummers, L. K., Malcarne, V. L., Mayes, M. D., Richard, M., Wojeck, R. K., Worron-Sauvé, M., Hudson, M., Mouthon, L., Benedetti, A., Thombs, B. D., Adams, C. E., El-Baalbaki, G., Fligelstone, K., Frech, T., Harel, D., Hinchcliff, M., Johnson, S. R., Larche, M., Leite, C., Nguyen, C., Nielsen, K., Pope, J., Rannou, F., Rodriguez-Reyna, T. S., Schouffoer, A. A., Suarez-Almazor, M. E., Agard, C., Alric, L., Andre, M., Beaslay, F., Bernstein, E. J., Berthier, S., Bissonnette, L., Blaise, S., Bories, E., Bruns, A., Cacciatore, C., Carreira, P., Casadevall, M., Chaigne, B., Chung, L. R. D., Crichi, B., Deltombe, T., Denton, C., Desroche, T., Domsic, R., Dunne, J., Dunogue, B., Fare, R., Farge-Bancel, D., Fortin, P. R., Gauzere, L., Gerber, A., Gordon, J. K., Granel-Rey, B., Guffroy, A., Gyger, G., Hachulla, E., Hoa, S., Hughes, M., Ikic, A., Khalidi, N., Lakin, K. S., Lambert, Marc, Launay, David, Lee, Y. C., Legendre, P., Maillard, H., Maltez, N., Manning, J., Marie, I., Lopez, M. M., Martin, T., Masetto, A., Mekinian, A., Diaz, S. M., Mourguet, M., Nikpour, M., Olagne, L., Poindron, V., Proudman, S., Pugnet, G., Raffray, L., Regent, A., Renou, F., Riviere, S., Robinson, D., Almazar, E. R., Roux, S., Smets, P., Sobanski, V., Spiera, R. F., Steen, V., Sutton, E., Thorne, C., Vagner, D., Varga, J., Wilcox, P., Ayala, M. C., Cook, V., Santo, C. D., Dal Santo, T., d'Onofrio, M., Hu, S. P., Nassar, E. L., Neyer, M. A., Provencher, S. |
| Συνεισφορές: | Radboud University Nijmegen, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Institute for Translational Research in Inflammation - U 1286 (INFINITE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| Πηγή: | ISSN: 1462-0324. |
| Στοιχεία εκδότη: | CCSD Oxford University Press (OUP) |
| Έτος έκδοσης: | 2024 |
| Συλλογή: | LillOA (HAL Lille Open Archive, Université de Lille) |
| Θεματικοί όροι: | [SDV]Life Sciences [q-bio] |
| Περιγραφή: | International audience ; ObjectivesThe objectives of this study were to compare fatigue in a large multinational SSc cohort with general population data and identify associated sociodemographic, lifestyle and SSc disease factors.MethodsScleroderma Patient-centered Intervention Network Cohort participants completed the Patient-Reported Outcomes Measurement Information System-29 v2.0 fatigue domain. T-scores were compared with the USA general population (mean = 50; s.d. = 10). Multivariable linear regression was used to assess associations with sociodemographic, lifestyle, and disease-related variables.ResultsAmong the 2385 participants [mean age 54.9 (s.d. = 12.6) years, 87% female, 38% dcSSc], the mean fatigue T-score was 54.6 (s.d. = 11.0); 438 (18%) reported mild fatigue, 641 (27%) moderate fatigue, and 180 (8%) severe fatigue. Fatigue was independently associated with sociodemographic factors age [−0.10 points per year, (95% CI −0.14, −0.07)], male sex [−1.67 points, (−2.96, −0.37)], non-married status [0.97 points (0.04, 1.89)] and country [reference USA; France −2.35 points (−3.48, −1.21) and UK 2.38 points (0.80, 3.97)], and lifestyle factors smoking [4.16 points (2.52, 5.80)], alcohol consumption [−0.18 points per drink per week (−0.28, −0.07)] and BMI [0.34 points per unit (0.27, 0.42)]. Fatigue was associated with disease-related factors, including gastrointestinal involvement [4.21 points (2.99, 5.43)], digital ulcers [1.51 points, (0.25, 2.77)], moderate small joint contractures (1.41 points [0.13, 2.69]), RA [4.34 points (2.37, 6.31)] and SS [1.89 points (0.23, 3.55)]. When pain was included in the model, its association was large [2.19 points (2.03, 2.34)], and interstitial lung disease was also associated [1.21 points (0.42, 2.00)].ConclusionIn people with SSc, fatigue scores were substantially higher than in the general population and associated with multiple disease factors, including gastrointestinal involvement, several painful disease manifestations, and lung involvement. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39447026; PUBMED: 39447026 |
| DOI: | 10.1093/rheumatology/keae570 |
| Διαθεσιμότητα: | https://lilloa.hal.science/hal-05325496 https://lilloa.hal.science/hal-05325496v1/document https://lilloa.hal.science/hal-05325496v1/file/keae570.pdf https://doi.org/10.1093/rheumatology/keae570 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Αριθμός Καταχώρησης: | edsbas.F071B476 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1093/rheumatology/keae570 |
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