Academic Journal
Predictive potential of circular walking in prodromal Parkinson's disease.
| Τίτλος: | Predictive potential of circular walking in prodromal Parkinson's disease. |
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| Συγγραφείς: | Micó-Amigo, M Encarna, Kingma, Idsart, Maetzler, Walter, van Dieën, Jaap H, Heinzel, Sebastian, Solbrig, Susanne, Hobert, Markus A., Elshehabi, Morad, Brockmann, Kathrin, Metzger, Florian, van Lummel, Rob C, Berg, Daniela |
| Πηγή: | Journal of Parkinson's Disease 15(1), 1877718X241306141 (2025). doi:10.1177/1877718X241306141 |
| Στοιχεία εκδότη: | IOS Press |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | info:eu-repo/classification/ddc/610, Parkinson Disease: complications, Humans, Parkinson Disease: diagnosis, Parkinson Disease: physiopathology, Male, Female, Prodromal Symptoms, Aged, Middle Aged, Walking: physiology, Case-Control Studies, Prospective Studies, Gait Disorders, Neurologic: etiology, Neurologic: diagnosis, Neurologic: physiopathology, Accelerometry: instrumentation, Gait: physiology, Gait Analysis: methods, Accelerometry, circular walking, gait analysis, idiopathic Parkinson's disease |
| Θέμα γεωγραφικό: | DE |
| Περιγραφή: | BackgroundDevelopment of objective, reliable and easy-to-use methods to detect the onset of motor changes in Parkinson's disease (PD) is required to identify the temporal window in which neuromodulatory therapies could be implemented. Turning impairments are present at early stages of PD. However, it is unclear, to date, whether circular walking is also altered in prodromal PD.ObjectiveExplore the predictive potential of circular walking in prodromal PD.MethodsWe included 102 subjects from a nine-year prospective cohort study (with 712 participants) in the current nested case-control analysis: 16 diagnosed with PD during follow-up (incident PD) and 96 healthy controls, matched in gender, age, and education with a 1:6 ratio. Forty-one gait features were extracted from baseline assessments with accelerometers under single and dual-tasking conditions. A Cox proportional hazards regression analysis was used to test the temporal association of non-correlated gait features to the probability of being diagnosed with PD.ResultsWe identified associations between time from baseline measurement to PD diagnosis for eleven gait features, mostly based on harmonic ratios, step and stride variability, and index of harmonicity, partially in combination with gait speed. Most significant associations indicated that low gait symmetry and low rhythmicity were associated with larger hazard of being diagnosed with PD. Area under the curve ranged 0.63-0.69.ConclusionsDespite low sensitivity and specificity, the findings potentially reflect prodromal motor impairments of PD manifested during circular walking, assessed quantitatively with a low-cost and wearable instrument. This will contribute to the characterization of pre-diagnostic PD motor symptoms. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| ISSN: | 1877-718X 1877-7171 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/pmid:39973512; info:eu-repo/semantics/altIdentifier/issn/1877-718X; info:eu-repo/semantics/altIdentifier/issn/1877-7171; https://pub.dzne.de/record/277793 |
| Διαθεσιμότητα: | https://pub.dzne.de/record/277793 https://pub.dzne.de/search?p=id:%22DZNE-2025-00471%22 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.EE276303 |
| Βάση Δεδομένων: | BASE |
| ISSN: | 1877718X 18777171 |
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