Academic Journal
Left ventricular outflow tract obstruction and myocardial edema burden in Takotsubo syndrome: acute and long-term outcomes—insights from the EVOLUTION registry
| Τίτλος: | Left ventricular outflow tract obstruction and myocardial edema burden in Takotsubo syndrome: acute and long-term outcomes—insights from the EVOLUTION registry |
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| Συγγραφείς: | Cau R., Santoro F., Pontone G., Muscogiuri G., Gatti M., Montisci R., Gravina M., Normant S., Catapano F., D'Angelo T., Esposito A., Meloni A., Ciolina F., Negri F., Pisu F., Lisi C., Imazio M., Palmisano A., Marchetti M. F., Galea N., Volpe A., Lanzafame L., Pambianchi G., Clemente A., Dacher J. N., Bischoff L., Luetkens J., Arcari L., Saba L. |
| Συνεισφορές: | Cau, R., Santoro, F., Pontone, G., Muscogiuri, G., Gatti, M., Montisci, R., Gravina, M., Normant, S., Catapano, F., D'Angelo, T., Esposito, A., Meloni, A., Ciolina, F., Negri, F., Pisu, F., Lisi, C., Imazio, M., Palmisano, A., Marchetti, M. F., Galea, N., Volpe, A., Lanzafame, L., Pambianchi, G., Clemente, A., Dacher, J. N., Bischoff, L., Luetkens, J., Arcari, L., Saba, L. |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Università degli Studi di Udine: CINECA IRIS |
| Θεματικοί όροι: | Cardiovascular magnetic resonance, LVOTO, Myocardial edema, Prognosi, Takotsubo syndrome |
| Περιγραφή: | Objective: To evaluate the clinical and CMR characteristics and the in-hospital and long-term outcomes of patients with Takotsubo syndrome (TTS) and left ventricular outflow tract obstruction (LVOTO). Material and method: This sub-analysis of the multicenter retrospective EVOLUTION registry included patients with TTS enrolled between November 21, 2007, and December 22, 2024, who underwent CMR within 5 days of echocardiographic assessment. Patients were stratified according to the presence or absence of LVOTO. Results: A total of 249 patients were included (226 women [90.8%]; mean age 70.6 ± 10.9 years), of whom 26 (10.4%) had LVOTO. Patients with LVOTO exhibited higher left ventricular mass, greater basal septal wall thickness, and more extensive T2-STIR involvement. Among CMR parameters, the number of T2-STIR-positive segments was independently associated with the presence of LVOTO (OR = 1.38, 95% CI: 1.17–1.63, p = 0.001). In-hospital complications, including pulmonary edema and cardiogenic shock, were more frequent among patients with LVOTO (34.6% vs. 15.8%; p = 0.018), and LVOTO remained independently associated with in-hospital complications on exploratory multivariable analysis (OR = 3.16, 95% CI: 1.08–9.26, p = 0.035). No significant association was observed between LVOTO and long-term MACE (HR 1.523, 95% CI 0.641–3.620; p = 0.340). Conclusion: LVOTO in patients with TTS, is independently associated with the extent of myocardial edema, and is more frequently observed in patients who experience in-hospital complications. No significant association with long-term MACE was found, though the limited number of events and wide confidence interval warrant cautious interpretation. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:001877446200001; volume:464; issue:134777; journal:INTERNATIONAL JOURNAL OF CARDIOLOGY; https://hdl.handle.net/11390/1341907 |
| DOI: | 10.1016/j.ijcard.2026.134777 |
| Διαθεσιμότητα: | https://hdl.handle.net/11390/1341907 https://doi.org/10.1016/j.ijcard.2026.134777 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.E965CC0F |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1016/j.ijcard.2026.134777 |
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