Academic Journal
Early and late stage dependent antıcancer effects of laurus NOBİLİS seed extracts on pc3 prostate cancer cells ; Laurus nobilis tohum ekstrelerinin PC3 prostat kanseri hücreleri üzerindeki erken ve geç evre bağımlı antikanser etkileri
| Τίτλος: | Early and late stage dependent antıcancer effects of laurus NOBİLİS seed extracts on pc3 prostate cancer cells ; Laurus nobilis tohum ekstrelerinin PC3 prostat kanseri hücreleri üzerindeki erken ve geç evre bağımlı antikanser etkileri |
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| Συγγραφείς: | Hacıoğlu , Nelin |
| Στοιχεία εκδότη: | Kocaeli Üniversitesi Kütüphane ve Dok.Dai. Başk. |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Balıkesir University Institutional Repository (DSpace@Balıkesir) |
| Θεματικοί όροι: | Laurus Nobilis, Prostate Cancer, Seed Extracts, Stagedependent Effects, Anticancer Activity, Prostat Kanseri, Tohum Özleri, Aşamaya Bağlı Etkiler, Antikanser Aktivite |
| Περιγραφή: | Objective: This study explored the anticancer properties of Laurus nobilis seed extracts at different maturity stages on PC3 prostate cancer cells, aiming to understand how developmental stages influence biological activities. Methods: Extracts from early-stage (green) and late-stage (black) L. nobilis seeds were tested on PC3 cells. Cytotoxicity, cell migration, wound healing, and gene expression were analyzed. HUVEC cells were used to assess toxicity on normal cells. Results: Early-stage extracts showed low cytotoxicity and promoted cell migration and wound healing. Late-stage extracts exhibited potent dose-dependent cytotoxicity and significantly inhibited cell migration. Both extracts demonstrated lower toxicity towards HUVEC cells. Gene expression analysis revealed suppression of epithelial-mesenchymal transition and migration in cells treated with late-stage extracts. Conclusion: The study highlights the stage-dependent anticancer potential of L. nobilis seed extracts. Late-stage extracts showed promising anticancer effects, while early-stage extracts promoted cell growth. These findings emphasize the importance of harvest time and maturity stage in determining the biological activity of L. nobilis extracts, providing valuable insights for future anticancer research and applications. ; Amaç: Bu çalışma, gelişim aşamalarının biyolojik aktiviteleri nasıl etkilediğini anlamak amacıyla, farklı olgunluk aşamalarındaki Laurus nobilis tohum özütlerinin PC3 prostat kanseri hücreleri üzerindeki antikanser özelliklerini araştırmıştır. Yöntem: Erken aşama (yeşil) ve geç aşama (siyah) L. nobilis tohumlarından elde edilen özütler PC3 hücreleri üzerinde test edilmiştir. Sitotoksisite, hücre göçü, yara iyileşmesi ve gen ekspresyonu analiz edilmiştir. Normal hücreler üzerindeki toksisiteyi değerlendirmek için HUVEC hücreleri kullanılmıştır Bulgular: Erken aşama özütleri düşük sitotoksisite göstermiş ve hücre göçünü ve yara iyileşmesini teşvik etmiştir. Geç aşama özütleri, güçlü doz bağımlı sitotoksisite göstermiş ve hücre ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | Turkish |
| Relation: | Acta Medica Nicomedia; Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.53446/actamednicomedia.1799392; https://hdl.handle.net/20.500.12462/24381; 1397908 |
| DOI: | 10.53446/actamednicomedia.1799392 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.12462/24381 https://doi.org/10.53446/actamednicomedia.1799392 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.E9309E42 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.53446/actamednicomedia.1799392 |
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