Academic Journal
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes
| Τίτλος: | Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes |
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| Συγγραφείς: | Laan, C.M. van der, Ip, H.F., Schipper, M., Hottenga, J.J., St Pourcain, B., Zayats, T., Pool, R., Krapohl, E.M.L., Brikell, I., Artigas, M.S., Cabana-Domínguez, J., Llonga, N., Nolte, I.M., Bolhuis, K., Palviainen, T., Zafarmand, H., Gordon, S., Aliev, F., Burt, S.A., Wang, C.A., Saunders, G., Karhunen, V., Adkins, D.E., Border, R., Peterson, R.E., Prinz, J.A., Thiering, E., Vilor-Tejedor, N., Ahluwalia, T.S., Allegrini, A., Rimfeld, K., Chen, Q., Lu, Y., Martin, J., Bosch, R., Ramos-Quiroga, J.A., Neumann, A., Ensink, J., Grasby, K.L., Morosoli, J.J., Tong, X.R., Marrington, S., Scott, J.G., Shabalin, A.A., Corley, R., Evans, L.M., Sugden, K., Alemany, S., Sass, L., Vinding, R., Ehli, E.A., Hagenbeek, F.A., Derks, E.M., Larsson, H., Snieder, H., Cecil, C., Whipp, A.M., Korhonen, T., Vuoksimaa, E., Rose, R.J., Uitterlinden, A.G., Haavik, J., Harris, J.R., Helgeland, O., Johansson, S., Knudsen, G.P.S., Njolstad, P.R., Lu, Q., Rodriguez, A., Henders, A.K., Mamun, A., Najman, J.M., Brown, S., Hopfer, C., Krauter, K., Reynolds, C.A., Smolen, A., Stallings, M., Wadsworth, S., Wall, T.L., Eaves, L., Silberg, J.L., Miller, A., Havdahl, A., Llop, S., Lopez-Espinosa, M.J., Bonnelykke, K., Sunyer, J., Arseneault, L., Standl, M., Heinrich, J., Boden, J., Pearson, J., Horwood, J., Kennedy, M., Poulton, R., Maes, H.H., Hewitt, J., Copeland, W.E., Middeldorp, C.M., Williams, G.M., Wray, N., Järvelin, M.R., McGue, M., Iacono, W., Caspi, A., Moffitt, T.E., Whitehouse, A.J.O., Pennell, C.E., Klump, K.L., Jiang, C., Dick, D.M., Reichborn-Kjennerud, T., Martin, N.G., Medland, S.E., Vrijkotte, T., Kaprio, J., Tiemeier, H., Smith, G.D., Hartman, C.A., Oldehinkel, A.J., Casas, M., Ribasés, M., Lichtenstein, P., Lundström, S., Plomin, R., Bartels, M., Nivard, M.G., Boomsma, D.I. |
| Πηγή: | Nature Genetics |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Leiden Repository (Leiden University) |
| Περιγραφή: | We performed a genome-wide association meta-analysis (GWAMA) of 290,134 attention-deficit/hyperactivity disorder (ADHD) symptom measures of 70,953 unique individuals from multiple raters, ages and instruments (ADHD(SYMP)). Next, we meta-analyzed the results with a study of ADHD diagnosis (ADHD(OVERALL)). ADHD(SYMP) returned no genome-wide significant variants. We show that the combined ADHD(OVERALL) GWAMA identified 39 independent loci, of which 17 were new. Using a recently developed gene-mapping method, Fine-mapped Locus Assessment Model of Effector genes, we identified 22 potential ADHD effector genes implicating several new biological processes and pathways. Moderate negative genetic correlations (r(g) < -0.40) were observed with multiple cognitive traits. In three cohorts, polygenic scores (PGSs) based on ADHD(OVERALL) outperformed PGSs based on ADHD symptoms and diagnosis alone. Our findings support the notion that clinical ADHD is at the extreme end of a continuous liability that is indexed by ADHD symptoms. We show that including ADHD symptom counts helps to identify new genes implicated in ADHD. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://hdl.handle.net/1887/4302075 |
| DOI: | 10.1038/s41588-025-02295-y |
| Διαθεσιμότητα: | https://hdl.handle.net/1887/4302075 https://doi.org/10.1038/s41588-025-02295-y |
| Αριθμός Καταχώρησης: | edsbas.DEE798A |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1038/s41588-025-02295-y |
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