Academic Journal
A review of the prevention of mother-to-child transmission of human T-cell lymphotrophic virus type 1 (HTLV-1) with a proposed management algorithm
| Title: | A review of the prevention of mother-to-child transmission of human T-cell lymphotrophic virus type 1 (HTLV-1) with a proposed management algorithm |
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| Authors: | Barr, RS, Drysdale, SB, Boullier, M, Lyall, H, Cook, L, Collins, GP, Kelly, DF, Phelan, L, Taylor, GP |
| Publisher Information: | Frontiers Media |
| Publication Year: | 2025 |
| Collection: | Oxford University Research Archive (ORA) |
| Description: | Human T cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus that is endemic in a number of regions across the world. There are an estimated 5–10 million people infected worldwide. Japan is currently the only country with a national antenatal screening programme in place. HTLV-1 is primarily transmitted sexually in adulthood, however it can be transmitted from mother-to-child perinatally. This can occur transplacentally, during the birth process or via breastmilk. If HTLV-1 is transmitted perinatally then the lifetime risk of adult T cell leukemia/lymphoma rises from 5 to 20%, therefore prevention of mother-to-child transmission of HTLV-1 is a public health priority. There are reliable immunological and molecular tests available for HTLV-1 diagnosis during pregnancy and screening should be considered on a country by country basis. Further research on best management is needed particularly for pregnancies in women with high HTLV-1 viral load. A first step would be to establish an international registry of cases and to monitor outcomes for neonates and mothers. We have summarized key risk factors for mother-to-child transmission of HTLV-1 and subsequently propose a pragmatic guideline for management of mothers and infants in pregnancy and the perinatal period to reduce the risk of transmission. This is clinically relevant in order to reduce mother-to-child transmission of HTLV-1 and it's complications. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://doi.org/10.3389/fmed.2022.941647 |
| DOI: | 10.3389/fmed.2022.941647 |
| Availability: | https://doi.org/10.3389/fmed.2022.941647 https://ora.ox.ac.uk/objects/uuid:5d441ee4-4561-4654-9a19-85ed36543b88 |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: | edsbas.DA50748A |
| Database: | BASE |
| DOI: | 10.3389/fmed.2022.941647 |
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