Academic Journal
Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function
| Τίτλος: | Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function |
|---|---|
| Συγγραφείς: | Brito, C, Sousa, S |
| Συνεισφορές: | Instituto de Investigação e Inovação em Saúde |
| Στοιχεία εκδότη: | MDPI |
| Έτος έκδοσης: | 2020 |
| Συλλογή: | Repositório Aberto da Universidade do Porto |
| Θεματικοί όροι: | actomyosin cytoskeleton, cell adhesion, cell migration, NM2A activity regulation, NM2A filament assembly, non-muscle myosin 2A (NM2A), plasma membrane blebbing, Actomyosin / metabolism, Animals, Cell Adhesion / genetics, Cell Adhesion / physiology, Cell Membrane / genetics, Cell Membrane / metabolism, Cell Membrane / physiology, Cell Movement / genetics, Cell Movement / physiology, Cytoskeleton / metabolism, Embryonic Development / genetics, Embryonic Development / physiology, Humans, Kidney Diseases / genetics, Kidney Diseases / immunology, Kidney Diseases / metabolism, Myosin Heavy Chains / chemistry, Myosin Heavy Chains / genetics, Myosin Heavy Chains / metabolism, Myosins / metabolism, Neoplasms / genetics, Neoplasms / metabolism, Neurodegenerative Diseases / genetics |
| Περιγραφή: | Non-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from the early stages of development until adulthood. Due to its capacity to convert chemical energy into force, NM2A powers the contraction of the actomyosin cytoskeleton, required for proper cell division, adhesion and migration, among other cellular functions. Although NM2A has been extensively studied, new findings revealed that a lot remains to be discovered concerning its spatiotemporal regulation in the intracellular environment. In recent years, new functions were attributed to NM2A and its activity was associated to a plethora of illnesses, including neurological disorders and infectious diseases. Here, we provide a concise overview on the current knowledge regarding the structure, the function and the regulation of NM2A. In addition, we recapitulate NM2A-associated diseases and discuss its potential as a therapeutic target. ; This work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project POCI-01-0145-FEDER-030863 (PTDC/BIA-CEL/30863/2017). Publication Fees were supported by ICBAS, University of Porto. CB was supported by an FCT fellowship (SFRH/BD/112217/2015). S.S. received support from FCT in the framework of CEEC-Institutional 2017 program. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-CEL%2F30863%2F2017/PT; info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F112217%2F2015/PT; Cells, vol.9(7):1590; https://www.mdpi.com/2073-4409/9/7/1590; https://hdl.handle.net/10216/143490 |
| DOI: | 10.3390/cells9071590 |
| Διαθεσιμότητα: | https://hdl.handle.net/10216/143490 https://doi.org/10.3390/cells9071590 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.D6234A34 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.3390/cells9071590 |
|---|