The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer – a multicentre observational study

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer – a multicentre observational study
Συγγραφείς:	Khadhouri S., Gallagher K. M., MacKenzie K. R., Shah T. T., Gao C., Moore S., Zimmermann E. F., Edison E., Jefferies M., Nambiar A., Mannas M. P., Lee T., Marra G., Lillaz B., Gomez Rivas J., Olivier J., Assmus M. A., Ucar T., Claps F., Boltri M., Burnhope T., Nkwam N., Tanasescu G., Boxall N. E., Downey A. P., Lal A. A., Anton-Juanilla M., Clarke H., Lau D. H. W., Gillams K., Crockett M., Nielsen M., Takwoingi Y., Chuchu N., O'Rourke J., MacLennan G., McGrath J. S., Kasivisvanathan V., Chaudry A., Sharma A., Bennett A., Ahmad A., Abroaf A., Suliman A. M., Lloyd A., McKay A., Wong A., Silva A., Schneider A., MacKay A., Knight A., Grigorakis A., Bdesha A., Nagle A., Cebola A., Dhanasekaran A. K., Kondza A., Barcelos A., Galosi A. B., Ebur A., Minervini A., Russell A., Webb A., Garcia de Jalon A., Desai A., Czech A. K., Mainwaring A., Adimonye A., Das A., Figueiredo A., Villers A., Leminski A., Chippagiri A., Yildirim A., Voulgaris A. M., Uzan A., Oo A. M. M., Younis A., Zelhof B., Mukhtar B., Ayres B., Challacombe B., Sherwood B., Ristau B., Lai B., Nellensteijn B., Schreiter B., Trombetta C., Dowling C., Hobbs C., Benitez C. A. E., Lebacle C., Ho C. W. Y., Ng C. -F., Mount C., Lam C. M., Blick C., Brown C., Gallegos C., Higgs C., Browne C., McCann C., Alonso C. P., Beder D., Cohen D., Gordon D., Wilby D., Hrouda D., Karsza D., Mak D., Martin-Way D., Suthaharan D., Patel D., Carrion D. M., Nyanhongo D., Bass E., Mains E., Chau E., Castillo E. C., Day E., Desouky E., Gaines E., Papworth E., Yuruk E., Kilic E., Dinneen E., Palagonia E., Xylinas E., Khawaja F., Cimarra F., Bardet F., Kum F., Peters F., Kovacs G., Hellawell G., Tasso G., Lam G., La Montagna G., Pizzuto G., Lenart G., Ozgur G., Bi H., Lyons H., Warren H., Ahmed H., Simpson H., Burden H., Gresty H., Pita H. R., Serag H., Kynaston H., Crawford-Smith H., Mostafid H., Otaola-Arca H., Fen Koo H., Ibrahim I., Ouzaid I., Puche-Sanz I., Tomaskovic I., Tinay I., Sahibzada I., Thangasamy I., Cadena I. R., Irani J., Udzik J., Brittain J., Catto J., Green J., Tweedle J., Hernando J. B., Leask J., Kalsi J., Frankel J., Toniolo J., Raman J. D., Courcier J., Kumaradeevan J., Clark J., Jones J., Teoh J. Y. -C., Iacovou J., Kelly J., Selph J. P., Aning J., Deeks J., Maw J., Herranz-Yague J. A., Nolazco J. I., Cozar-Olmo J. M., Bagley J., Jelski J., Norris J., Testa J., Meeks J., Hernandez J., Vasquez J. L., Randhawa K., Dhera K., Gronostaj K., Houlton K., Lehman K., Adasonla K., Brown K., Murtagh K., Mistry K., Davenport K., Kitamura K., Derbyshire L., Clarke L., Morton L., Martinez L., Goldsmith L., Paramore L., Cormier L., Dell'Atti L., Simmons L., Martinez-Pineiro L., Rico L., Chan L., Forster L., Ma L., Moore M., Gallego M. C., Freire M. J., Emberton M., Feneley M., Rivero M. V. M., Pirsa M., Talle M., Liew M., Trail M., Cooper M., Kulkarni M., Ager M., He M., Li M., Omran Breish M., Tarin M., Aldiwani M., Matanhelia M., Pasha M., Akalin M. K., Abdullah N., Hale N., Gadiyar N., Kocher N., Bullock N., Campain N., Pavan N., Al-Ibraheem N., Bhatt N., Bedi N., Shrotri N., Lobo N., Balderas O., Kouli O., Capoun O., Manjavacas P. O., Gontero P., Mariappan P., Marchinena P. G., Erotocritou P., Sweeney P., Planelles P., Acher P., Black P. C., Osei-Bonsu P. K., Ostergren P., Smith P., Willemse P. -P. M., Chlosta P. L., Ul Ain Q., Barratt R., Esler R., Khalid R., Hsu R., Stamirowski R., Mangat R., Cruz R., Ellis R., Adams R., Hessell R., Oomen R. J. A., McConkey R., Ritchie R., Jarimba R., Chahal R., Andres R. M., Hawkins R., David R., Manecksha R. P., Agrawal S., Hamid S. S., Deem S., Goonewardene S., Swami S. K., Hori S., Khan S., Inder S. M., Sangaralingam S., Marathe S., Raveenthiran S., Horie S., Sengupta S., Parson S., Parker S., Hawlina S., Williams S., Mazzoli S., Kata S. G., Lopes S. P., Ramos S., Rai S., Rintoul-Hoad S., O'Meara S., Morris S., Turner S., Venturini S., Almpanis S., Joniau S., Jain S., Mallett S., Nikles S., Yan S. S., Drake T., Toma T., Plo T. C., Bonnin T., Muilwijk T., Wollin T., Chu T. S. M., Appanna T., Brophy T., Ellul T., Austin T., Smrkolj T., Rowe T., Sukhu T., Patel T., Garg T., Caskurlu T., Bele U., Haroon U., Crespo-Atin V., Cortes V. P., Poves V. C., Gnanapragasam V., Gauhar V., During V., Kumar V., Fiala V., Mahmalji W., Lam W., Chin Y. F., Filtekin Y., Phan Y. C., Ibrahim Y., Glaser Z. A., Adwin Z., Qin Z., Zotter Z., Zainuddin Z.
Συνεισφορές:	Khadhouri, S., Gallagher, K. M., Mackenzie, K. R., Shah, T. T., Gao, C., Moore, S., Zimmermann, E. F., Edison, E., Jefferies, M., Nambiar, A., Mannas, M. P., Lee, T., Marra, G., Lillaz, B., Gomez Rivas, J., Olivier, J., Assmus, M. A., Ucar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N. E., Downey, A. P., Lal, A. A., Anton-Juanilla, M., Clarke, H., Lau, D. H. W., Gillams, K., Crockett, M., Nielsen, M., Takwoingi, Y., Chuchu, N., O'Rourke, J., Maclennan, G., Mcgrath, J. S., Kasivisvanathan, V., Chaudry, A., Sharma, A., Bennett, A., Ahmad, A., Abroaf, A., Suliman, A. M., Lloyd, A., Mckay, A., Wong, A., Silva, A., Schneider, A., Mackay, A., Knight, A., Grigorakis, A., Bdesha, A., Nagle, A., Cebola, A., Dhanasekaran, A. K., Kondza, A., Barcelos, A., Galosi, A. B., Ebur, A., Minervini, A., Russell, A., Webb, A., Garcia de Jalon, A., Desai, A., Czech, A. K., Mainwaring, A., Adimonye, A., Das, A., Figueiredo, A., Villers, A., Leminski, A., Chippagiri, A., Yildirim, A., Voulgaris, A. M., Uzan, A., Oo, A. M. M., Younis, A., Zelhof, B., Mukhtar, B., Ayres, B., Challacombe, B., Sherwood, B., Ristau, B., Lai, B., Nellensteijn, B., Schreiter, B., Trombetta, C., Dowling, C., Hobbs, C., Benitez, C. A. E., Lebacle, C., Ho, C. W. Y., Ng, C. -F., Mount, C., Lam, C. M., Blick, C., Brown, C., Gallegos, C., Higgs, C.
Έτος έκδοσης:	2021
Συλλογή:	Università Politecnica delle Marche: IRIS
Θεματικοί όροι:	bladder cancer, cancer prevalence, haematuria, hematuria, prostate cancer, renal cancer, upper tract urothelial cancer, urinary tract cancer, Adult, Aged, Female, Human, Kidney Neoplasm, Male, Middle Aged, Prospective Studie, Referral and Consultation, Ureteral Neoplasm, Urinary Bladder Neoplasms
Περιγραφή:	Objective: To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. Patients and Methods: This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries. Results: Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001). Conclusions: A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer.
Τύπος εγγράφου:	article in journal/newspaper
Γλώσσα:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/33991045; info:eu-repo/semantics/altIdentifier/wos/WOS:000693631300001; volume:128; issue:4; firstpage:440; lastpage:450; numberofpages:11; journal:BJU INTERNATIONAL; https://hdl.handle.net/11566/296889
DOI:	10.1111/bju.15483
Διαθεσιμότητα:	https://hdl.handle.net/11566/296889 https://doi.org/10.1111/bju.15483
Rights:	info:eu-repo/semantics/openAccess
Αριθμός Καταχώρησης:	edsbas.D606F767
Βάση Δεδομένων:	BASE

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Περιγραφή
DOI:	10.1111/bju.15483