Academic Journal
Synthesis and biodistribution of the Tc-99m nitrido complex with 2-(4-nitro-1H-imidazolyl)ethyl dithiocarbamate (NIET)
| Τίτλος: | Synthesis and biodistribution of the Tc-99m nitrido complex with 2-(4-nitro-1H-imidazolyl)ethyl dithiocarbamate (NIET) |
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| Συγγραφείς: | Chu, TW, Li, RJ, Hu, SW, Wang, Y, Liu, XQ, Wang, XY |
| Συνεισφορές: | Chu, TW (reprint author), Peking Univ, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China., Peking Univ, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China. |
| Πηγή: | SCI |
| Στοιχεία εκδότη: | journal of radioanalytical and nuclear chemistry |
| Έτος έκδοσης: | 2004 |
| Συλλογή: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| Θεματικοί όροι: | TUMOR HYPOXIA, IMAGING AGENT, NITROIMIDAZOLES, METRONIDAZOLE, OXYGENATION, BEARING |
| Περιγραφή: | In order to visualize hypoxic tissues, a Tc-99m complex containing a nitroimidazole group was evaluated. A new dithiocarbamate ligand, potassium 2-(4-nitro-1H-imidazolyl)ethyl dithiocarbamate (NIET) was synthesized. The corresponding nitridotechnetium complex was formed by a ligand exchange method. The dependence of the radiolabeling yield of (TcN)-Tc-99m-NIET on the amount of added stannous chloride and other parameters was screened by the normal procedure. Under optimized labeling conditions, the radiolabeling yield of (TcN)-Tc-99m-NIET is about 90%. The biodistribution of (TcN)-Tc-99m-NIET in mice bearing S180 tumor demonstrated some uptake in tumor and a tumor-to-muscle ratio of 3.14 at 4 hours after injection. ; Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; SCI(E) ; 10 ; ARTICLE ; 1 ; 199-202 ; 261 |
| Τύπος εγγράφου: | journal/newspaper |
| Γλώσσα: | English |
| Relation: | 1009799; https://hdl.handle.net/20.500.11897/151632; WOS:000221903800029 |
| DOI: | 10.1023/B:JRNC.0000030957.77606.00 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.11897/151632 https://doi.org/10.1023/B:JRNC.0000030957.77606.00 |
| Αριθμός Καταχώρησης: | edsbas.D4E7710 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1023/B:JRNC.0000030957.77606.00 |
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