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A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal Activity for Urinary Tract Implantable Devices

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Τίτλος: A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal Activity for Urinary Tract Implantable Devices
Συγγραφείς: Yiran Jia, Hongyu Zhang
Έτος έκδοσης: 2025
Συλλογή: The University of Auckland: Figshare
Θεματικοί όροι: Microbiology, Physiology, Biotechnology, Developmental Biology, Cancer, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, responsive bactericidal activity, responsive bactericidal ability, offer passive protection, driven urinary alkalization, conventional antimicrobial strategies, catalyzed urea hydrolysis, bacterial biofilm formation, microscopic adhesion forces, responsive bactericidal performance, hydrophilic lubricating coating, bacterial adhesion, urea bond, hydrophilic coatings, antibacterial adhesion, vivo <, vitro <, ureteral stents, synergistic function, stone deposition, stent surface, remained inactive
Περιγραφή: The implantation of ureteral stents frequently induces complications, such as bacterial biofilm formation and stone deposition, which are caused by bacterial adhesion on the stent surface and also urease-driven urinary alkalization. Conventional antimicrobial strategies, including drug-eluting or hydrophilic coatings, offer passive protection and may result in antibiotic resistance. To overcome these limitations, we developed a new hydrophilic lubricating coating with the synergistic function of antibacterial adhesion and urease-responsive bactericidal ability. The coating, based on urease-catalyzed urea hydrolysis, embedded sulfamethoxazole, which remained inactive until urease hydrolyzed the urea bond. By investigation of the microscopic adhesion forces, the coating was proven to have excellent antibacterial adhesion ability. Furthermore, from both in vitro and in vivo tests with typical urease-active bacteria, the coating showed remarkable urease-responsive bactericidal performance. This design enhanced antimicrobial efficacy while reducing toxicity and nonspecific release, thereby offering significant potential for improving the performance of ureteral stents.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: unknown
DOI: 10.1021/acsami.5c07616.s001
Διαθεσιμότητα: https://doi.org/10.1021/acsami.5c07616.s001
https://figshare.com/articles/journal_contribution/A_Hydrophilic_Lubricating_Coating_with_Dual_Functions_of_Antibacterial_Adhesion_and_Urease-Responsive_Bactericidal_Activity_for_Urinary_Tract_Implantable_Devices/29208282
Rights: CC BY-NC 4.0
Αριθμός Καταχώρησης: edsbas.D3C8447
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.1021/acsami.5c07616.s001#
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 977.8095703125
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  Data: A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal Activity for Urinary Tract Implantable Devices
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– Name: Abstract
  Label: Description
  Group: Ab
  Data: The implantation of ureteral stents frequently induces complications, such as bacterial biofilm formation and stone deposition, which are caused by bacterial adhesion on the stent surface and also urease-driven urinary alkalization. Conventional antimicrobial strategies, including drug-eluting or hydrophilic coatings, offer passive protection and may result in antibiotic resistance. To overcome these limitations, we developed a new hydrophilic lubricating coating with the synergistic function of antibacterial adhesion and urease-responsive bactericidal ability. The coating, based on urease-catalyzed urea hydrolysis, embedded sulfamethoxazole, which remained inactive until urease hydrolyzed the urea bond. By investigation of the microscopic adhesion forces, the coating was proven to have excellent antibacterial adhesion ability. Furthermore, from both in vitro and in vivo tests with typical urease-active bacteria, the coating showed remarkable urease-responsive bactericidal performance. This design enhanced antimicrobial efficacy while reducing toxicity and nonspecific release, thereby offering significant potential for improving the performance of ureteral stents.
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      – Type: doi
        Value: 10.1021/acsami.5c07616.s001
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      – Text: unknown
    Subjects:
      – SubjectFull: Microbiology
        Type: general
      – SubjectFull: Physiology
        Type: general
      – SubjectFull: Biotechnology
        Type: general
      – SubjectFull: Developmental Biology
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      – SubjectFull: Cancer
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      – SubjectFull: Computational Biology
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      – SubjectFull: Space Science
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      – SubjectFull: Biological Sciences not elsewhere classified
        Type: general
      – SubjectFull: Chemical Sciences not elsewhere classified
        Type: general
      – SubjectFull: responsive bactericidal activity
        Type: general
      – SubjectFull: responsive bactericidal ability
        Type: general
      – SubjectFull: offer passive protection
        Type: general
      – SubjectFull: driven urinary alkalization
        Type: general
      – SubjectFull: conventional antimicrobial strategies
        Type: general
      – SubjectFull: catalyzed urea hydrolysis
        Type: general
      – SubjectFull: bacterial biofilm formation
        Type: general
      – SubjectFull: microscopic adhesion forces
        Type: general
      – SubjectFull: responsive bactericidal performance
        Type: general
      – SubjectFull: hydrophilic lubricating coating
        Type: general
      – SubjectFull: bacterial adhesion
        Type: general
      – SubjectFull: urea bond
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      – SubjectFull: hydrophilic coatings
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      – SubjectFull: antibacterial adhesion
        Type: general
      – SubjectFull: vivo <
        Type: general
      – SubjectFull: vitro <
        Type: general
      – SubjectFull: ureteral stents
        Type: general
      – SubjectFull: synergistic function
        Type: general
      – SubjectFull: stone deposition
        Type: general
      – SubjectFull: stent surface
        Type: general
      – SubjectFull: remained inactive
        Type: general
    Titles:
      – TitleFull: A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal Activity for Urinary Tract Implantable Devices
        Type: main
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              Type: published
              Y: 2025
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