Academic Journal
A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal Activity for Urinary Tract Implantable Devices
| Τίτλος: | A Hydrophilic Lubricating Coating with Dual Functions of Antibacterial Adhesion and Urease-Responsive Bactericidal Activity for Urinary Tract Implantable Devices |
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| Συγγραφείς: | Yiran Jia, Hongyu Zhang |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | The University of Auckland: Figshare |
| Θεματικοί όροι: | Microbiology, Physiology, Biotechnology, Developmental Biology, Cancer, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, responsive bactericidal activity, responsive bactericidal ability, offer passive protection, driven urinary alkalization, conventional antimicrobial strategies, catalyzed urea hydrolysis, bacterial biofilm formation, microscopic adhesion forces, responsive bactericidal performance, hydrophilic lubricating coating, bacterial adhesion, urea bond, hydrophilic coatings, antibacterial adhesion, vivo <, vitro <, ureteral stents, synergistic function, stone deposition, stent surface, remained inactive |
| Περιγραφή: | The implantation of ureteral stents frequently induces complications, such as bacterial biofilm formation and stone deposition, which are caused by bacterial adhesion on the stent surface and also urease-driven urinary alkalization. Conventional antimicrobial strategies, including drug-eluting or hydrophilic coatings, offer passive protection and may result in antibiotic resistance. To overcome these limitations, we developed a new hydrophilic lubricating coating with the synergistic function of antibacterial adhesion and urease-responsive bactericidal ability. The coating, based on urease-catalyzed urea hydrolysis, embedded sulfamethoxazole, which remained inactive until urease hydrolyzed the urea bond. By investigation of the microscopic adhesion forces, the coating was proven to have excellent antibacterial adhesion ability. Furthermore, from both in vitro and in vivo tests with typical urease-active bacteria, the coating showed remarkable urease-responsive bactericidal performance. This design enhanced antimicrobial efficacy while reducing toxicity and nonspecific release, thereby offering significant potential for improving the performance of ureteral stents. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | unknown |
| DOI: | 10.1021/acsami.5c07616.s001 |
| Διαθεσιμότητα: | https://doi.org/10.1021/acsami.5c07616.s001 https://figshare.com/articles/journal_contribution/A_Hydrophilic_Lubricating_Coating_with_Dual_Functions_of_Antibacterial_Adhesion_and_Urease-Responsive_Bactericidal_Activity_for_Urinary_Tract_Implantable_Devices/29208282 |
| Rights: | CC BY-NC 4.0 |
| Αριθμός Καταχώρησης: | edsbas.D3C8447 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1021/acsami.5c07616.s001 |
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