Academic Journal
Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies
| Τίτλος: | Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies |
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| Συγγραφείς: | Awad K, Mohammed M, Zaki MM, Abushouk AI, Lip GYH, Blaha MJ, Lavie CJ, Toth PP, Jukema JW, Sattar N, Banach M, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP), Cicero AFG |
| Συνεισφορές: | Awad K, Mohammed M, Zaki MM, Abushouk AI, Lip GYH, Blaha MJ, Lavie CJ, Toth PP, Jukema JW, Sattar N, Banach M, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP), Cicero AFG |
| Έτος έκδοσης: | 2021 |
| Συλλογή: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Θεματικοί όροι: | Mortality, Myocardial infarction, Older, Primary prevention, Statin, Stroke |
| Περιγραφή: | Background: Current evidence from randomized controlled trials on statins for primary prevention of cardiovascular disease (CVD) in older people, especially those aged > 75 years, is still lacking. We conducted a systematic review and meta-analysis of observational studies to extend the current evidence about the association of statin use in older people primary prevention group with risk of CVD and mortality. Methods: PubMed, Scopus, and Embase were searched from inception until March 18, 2021. We included observational studies (cohort or nested case-control) that compared statin use vs non-use for primary prevention of CVD in older people aged ≥ 65 years; provided that each of them reported the risk estimate on at least one of the following primary outcomes: all cause-mortality, CVD death, myocardial infarction (MI), and stroke. Risk estimates of each relevant outcome were pooled as a hazard ratio (HR) with a 95% confidence interval (CI) using the random-effects meta-analysis model. The quality of the evidence was rated using the GRADE approach. Results: Ten observational studies (9 cohorts and one case-control study; n = 815,667) fulfilled our criteria. The overall combined estimate suggested that statin therapy was associated with a significantly lower risk of all-cause mortality (HR: 0.86 [95% CI 0.79 to 0.93]), CVD death (HR: 0.80 [95% CI 0.78 to 0.81]), and stroke (HR: 0.85 [95% CI 0.76 to 0.94]) and a non-significant association with risk of MI (HR 0.74 [95% CI 0.53 to 1.02]). The beneficial association of statins with the risk of all-cause mortality remained significant even at higher ages (> 75 years old; HR 0.88 [95% CI 0.81 to 0.96]) and in both men (HR: 0.75 [95% CI: 0.74 to 0.76]) and women (HR 0.85 [95% CI 0.72 to 0.99]). However, this association with the risk of all-cause mortality remained significant only in those with diabetes mellitus (DM) (HR 0.82 [95% CI 0.68 to 0.98]) but not in those without DM. The level of evidence of all the primary outcomes was rated as "very low." Conclusions: ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | STAMPA |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34154589; info:eu-repo/semantics/altIdentifier/wos/WOS:000664118300001; volume:19; issue:1; firstpage:1; lastpage:17; numberofpages:17; journal:BMC MEDICINE; https://hdl.handle.net/11585/853235 |
| DOI: | 10.1186/s12916-021-02009-1 |
| Διαθεσιμότητα: | https://hdl.handle.net/11585/853235 https://doi.org/10.1186/s12916-021-02009-1 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) ; license uri:iris.PUB15 |
| Αριθμός Καταχώρησης: | edsbas.D3C27D7D |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1186/s12916-021-02009-1 |
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