Academic Journal
Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning.
| Title: | Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning. |
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| Authors: | Corthésy-Theulaz, I., Corthésy, B., Bachmann, D., Velin, D., Kraehenbuhl, J.P. |
| Publication Year: | 2003 |
| Collection: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Subject Terms: | Animals, Newborn, Antibodies, Bacterial/immunology, Antigens, Breast Feeding, Female, Helicobacter/immunology, Helicobacter Infections/immunology, Helicobacter Infections/prevention & control, Helicobacter pylori/enzymology, Helicobacter pylori/immunology, Immunity, Maternally-Acquired, Immunization, Mice, Milk/immunology, Urease/immunology, Weaning |
| Description: | The objective of this study was to examine the effect of breast-feeding by immunized dams on Helicobacter colonization in newborns. Urease-based immunization regimens failed to protect nursing pups against H. felis, whereas H. felis lysate-cholera toxin resulted in protection. This observation correlated with a high recognition of cell surface-expressed bacterial antigens by milk antibodies. Protection lasted until weaning, indicating that infection is maintained at undetectable levels by passive immunity but then resumes when breast-feeding stops. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 0019-9567 |
| Relation: | Infection and Immunity; https://iris.unil.ch/handle/iris/164494; serval:BIB_A5AD30D8F217; 000181926200074 |
| DOI: | 10.1128/IAI.71.4.2226-2229.2003 |
| Availability: | https://iris.unil.ch/handle/iris/164494 https://doi.org/10.1128/IAI.71.4.2226-2229.2003 |
| Accession Number: | edsbas.D2A2532B |
| Database: | BASE |
| ISSN: | 00199567 |
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| DOI: | 10.1128/IAI.71.4.2226-2229.2003 |