Academic Journal
Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study
| Title: | Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study |
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| Authors: | Yantus A.B. Neolaka*, .-, Yosep Lawa, .-, Magdarita Riwu, .-, Handoko Darmokoesoemo*, .-, Harsasi Setyawati, .-, Johnson Naat,, .-, Bernadeta Ayu Widyaningrum, .-, Uyiosa Osagie Aigbe,, .-, Kingsley Eghonghon Ukhurebor, .-, Robert Birundu Onyancha,, .-, Heri Septya Kusuma*, .- |
| Publisher Information: | Elsevier BV |
| Publication Year: | 2022 |
| Collection: | Airlangga University: UNAIR Repository |
| Subject Terms: | Q Science, Q Science (General), QD146-197 Inorganic chemistry |
| Description: | Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future. |
| Document Type: | article in journal/newspaper |
| File Description: | text |
| Language: | English |
| Relation: | https://repository.unair.ac.id/127531/1/C11.%20Fulltext.pdf; https://repository.unair.ac.id/127531/2/C11.%20Penilaian%20dan%20Validasi.pdf; https://repository.unair.ac.id/127531/3/C11.%20Similarity.pdf; Yantus A.B. Neolaka*, .- and Yosep Lawa, .- and Magdarita Riwu, .- and Handoko Darmokoesoemo*, .- and Harsasi Setyawati, .- and Johnson Naat,, .- and Bernadeta Ayu Widyaningrum, .- and Uyiosa Osagie Aigbe,, .- and Kingsley Eghonghon Ukhurebor, .- and Robert Birundu Onyancha,, .- and Heri Septya Kusuma*, .- (2022) Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study. Result in Chemistry, 4. pp. 1-9. ISSN 22117156 |
| Availability: | https://repository.unair.ac.id/127531/ https://repository.unair.ac.id/127531/1/C11.%20Fulltext.pdf https://repository.unair.ac.id/127531/2/C11.%20Penilaian%20dan%20Validasi.pdf https://repository.unair.ac.id/127531/3/C11.%20Similarity.pdf https://www.sciencedirect.com/science/article/pii/S2211715622002971?via%3Dihub |
| Accession Number: | edsbas.BA026CED |
| Database: | BASE |
| Description not available. |