Academic Journal
Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan
| Τίτλος: | Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan |
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| Συγγραφείς: | Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessi, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis |
| Συνεισφορές: | Panagiota Kalafati, Ioanna, Krongauz, David, Bosco, Alice, Noto, Antonio, Piras, Cristina, Kafyra, Maria, Dessi, Angelica, Mauri, Matteo, Atzori, Luigi, Weinberger, Adina, Fanos, Vassilio, Dedoussis, George V. |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Università degli Studi di Cagliari: UNICA IRIS |
| Θεματικοί όροι: | gut microbiome, interventions, metabolomics, obesity |
| Περιγραφή: | Obesity arises from intertwined and reciprocal diet-microbiome-host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle-related lifecourse dynamics from birth to older age, examines how GLP-1-based therapies may perturb gut ecology and metabolite output and surveys AI/ML frameworks for multi-omics integration. Plant-based, fiber-rich dietary patterns generally enrich saccharolytic guilds, boost SCFAs production, and modulate bile acid signaling, whereas Westernized patterns favor bile-tolerant, amino acid-fermenting consortia and proinflammatory metabolites. Preclinical data suggest that incretin-based therapies remodel the microbiome-metabolome axis, but human causal mediation remains unproven and observed changes may partly reflect weight loss or metabolic improvement. Function-centered metrics outperform phylum-level ratios for translation. Harmonized longitudinal cohorts and explainable ML-derived microbial and metabolomic signatures are now pivotal to identify responder subtypes and actionable microbe-metabolite targets, enabling precision nutrition alongside pharmacotherapy across the lifespan. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/42683734; journal:OBESITY REVIEWS; https://hdl.handle.net/11584/493647 |
| DOI: | 10.1111/obr.70220 |
| Διαθεσιμότητα: | https://hdl.handle.net/11584/493647 https://doi.org/10.1111/obr.70220 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.B67A5C3A |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1111/obr.70220 |
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