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Immunosupressive Phenolic Constituents from Hypericum montbretii Spach.

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Title: Immunosupressive Phenolic Constituents from Hypericum montbretii Spach.
Authors: Demirkiran, Ozlem, Mesaik, M. Ahmad, Beynek, Hayrettin, Abbaskhan, Ahmed, Choudhary, M. Iqbal
Publisher Information: Acg Publications
Publication Year: 2013
Collection: Trakya Üniversitesi: Açık Erişim Sistemi
Subject Terms: Hypericum Monbretii Spach, Phenolics, Immunomodulating Inhibitory Activity, Reactive Oxygen Species, T-Cell Proliferation, IL-2 Production, St-Johns-Wort, Alzheimers-Disease, Chemi-Luminescence, Oxidative Stress, Cell-Cultures, T-Cells, Antioxidants, Xanthones
Description: The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8 '' biapigenin (7), methyl chlorogenate (8), 5-O-p-coumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 mu g/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach. ; Higher Education Commission of Pakistan [20-684 RD 2007]; Trakya University Research Projects Commision [TUBAP-387]; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) ; This work was supported by a grant 20-684 R&D 2007 of Higher Education Commission of Pakistan, and grant TUBAP-387 of Trakya University Research Projects Commision. One of the authors (Ozlem Demirkiran) is grateful to the H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) for the financial support.
Document Type: article in journal/newspaper
Language: English
Relation: Records Of Natural Products; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.14551/21693; 210; 219; Q3; WOS:000319558500007
Availability: https://hdl.handle.net/20.500.14551/21693
Rights: info:eu-repo/semantics/closedAccess
Accession Number: edsbas.B5D7DE7A
Database: BASE
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  – Url: https://hdl.handle.net/20.500.14551/21693#
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PubType: Academic Journal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Immunosupressive Phenolic Constituents from Hypericum montbretii Spach.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Demirkiran%2C+Ozlem%22">Demirkiran, Ozlem</searchLink><br /><searchLink fieldCode="AR" term="%22Mesaik%2C+M%2E+Ahmad%22">Mesaik, M. Ahmad</searchLink><br /><searchLink fieldCode="AR" term="%22Beynek%2C+Hayrettin%22">Beynek, Hayrettin</searchLink><br /><searchLink fieldCode="AR" term="%22Abbaskhan%2C+Ahmed%22">Abbaskhan, Ahmed</searchLink><br /><searchLink fieldCode="AR" term="%22Choudhary%2C+M%2E+Iqbal%22">Choudhary, M. Iqbal</searchLink>
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Acg Publications
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2013
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Trakya Üniversitesi: Açık Erişim Sistemi
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hypericum+Monbretii+Spach%22">Hypericum Monbretii Spach</searchLink><br /><searchLink fieldCode="DE" term="%22Phenolics%22">Phenolics</searchLink><br /><searchLink fieldCode="DE" term="%22Immunomodulating+Inhibitory+Activity%22">Immunomodulating Inhibitory Activity</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+Oxygen+Species%22">Reactive Oxygen Species</searchLink><br /><searchLink fieldCode="DE" term="%22T-Cell+Proliferation%22">T-Cell Proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22IL-2+Production%22">IL-2 Production</searchLink><br /><searchLink fieldCode="DE" term="%22St-Johns-Wort%22">St-Johns-Wort</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimers-Disease%22">Alzheimers-Disease</searchLink><br /><searchLink fieldCode="DE" term="%22Chemi-Luminescence%22">Chemi-Luminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+Stress%22">Oxidative Stress</searchLink><br /><searchLink fieldCode="DE" term="%22Cell-Cultures%22">Cell-Cultures</searchLink><br /><searchLink fieldCode="DE" term="%22T-Cells%22">T-Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Xanthones%22">Xanthones</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8 '' biapigenin (7), methyl chlorogenate (8), 5-O-p-coumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 mu g/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach. ; Higher Education Commission of Pakistan [20-684 RD 2007]; Trakya University Research Projects Commision [TUBAP-387]; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) ; This work was supported by a grant 20-684 R&D 2007 of Higher Education Commission of Pakistan, and grant TUBAP-387 of Trakya University Research Projects Commision. One of the authors (Ozlem Demirkiran) is grateful to the H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) for the financial support.
– Name: TypeDocument
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  Data: article in journal/newspaper
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: Records Of Natural Products; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.14551/21693; 210; 219; Q3; WOS:000319558500007
– Name: URL
  Label: Availability
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  Data: https://hdl.handle.net/20.500.14551/21693
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: info:eu-repo/semantics/closedAccess
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.B5D7DE7A
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.B5D7DE7A
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Hypericum Monbretii Spach
        Type: general
      – SubjectFull: Phenolics
        Type: general
      – SubjectFull: Immunomodulating Inhibitory Activity
        Type: general
      – SubjectFull: Reactive Oxygen Species
        Type: general
      – SubjectFull: T-Cell Proliferation
        Type: general
      – SubjectFull: IL-2 Production
        Type: general
      – SubjectFull: St-Johns-Wort
        Type: general
      – SubjectFull: Alzheimers-Disease
        Type: general
      – SubjectFull: Chemi-Luminescence
        Type: general
      – SubjectFull: Oxidative Stress
        Type: general
      – SubjectFull: Cell-Cultures
        Type: general
      – SubjectFull: T-Cells
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Xanthones
        Type: general
    Titles:
      – TitleFull: Immunosupressive Phenolic Constituents from Hypericum montbretii Spach.
        Type: main
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          Name:
            NameFull: Demirkiran, Ozlem
      – PersonEntity:
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            NameFull: Mesaik, M. Ahmad
      – PersonEntity:
          Name:
            NameFull: Beynek, Hayrettin
      – PersonEntity:
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            NameFull: Abbaskhan, Ahmed
      – PersonEntity:
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            NameFull: Choudhary, M. Iqbal
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              M: 01
              Type: published
              Y: 2013
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