Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Immunosupressive Phenolic Constituents from Hypericum montbretii Spach. |
| Συγγραφείς: |
Demirkiran, Ozlem, Mesaik, M. Ahmad, Beynek, Hayrettin, Abbaskhan, Ahmed, Choudhary, M. Iqbal |
| Στοιχεία εκδότη: |
Acg Publications |
| Έτος έκδοσης: |
2013 |
| Συλλογή: |
Trakya Üniversitesi: Açık Erişim Sistemi |
| Θεματικοί όροι: |
Hypericum Monbretii Spach, Phenolics, Immunomodulating Inhibitory Activity, Reactive Oxygen Species, T-Cell Proliferation, IL-2 Production, St-Johns-Wort, Alzheimers-Disease, Chemi-Luminescence, Oxidative Stress, Cell-Cultures, T-Cells, Antioxidants, Xanthones |
| Περιγραφή: |
The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8 '' biapigenin (7), methyl chlorogenate (8), 5-O-p-coumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 mu g/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach. ; Higher Education Commission of Pakistan [20-684 RD 2007]; Trakya University Research Projects Commision [TUBAP-387]; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) ; This work was supported by a grant 20-684 R&D 2007 of Higher Education Commission of Pakistan, and grant TUBAP-387 of Trakya University Research Projects Commision. One of the authors (Ozlem Demirkiran) is grateful to the H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) for the financial support. |
| Τύπος εγγράφου: |
article in journal/newspaper |
| Γλώσσα: |
English |
| Relation: |
Records Of Natural Products; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.14551/21693; 210; 219; Q3; WOS:000319558500007 |
| Διαθεσιμότητα: |
https://hdl.handle.net/20.500.14551/21693 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Αριθμός Καταχώρησης: |
edsbas.B5D7DE7A |
| Βάση Δεδομένων: |
BASE |