Academic Journal
Voltammetric studies of the effect of Cisplatin-liposome on Hela cells
| Title: | Voltammetric studies of the effect of Cisplatin-liposome on Hela cells |
|---|---|
| Authors: | Ci, YX, Zhai, Q, Wang, S, Chang, WB, Zhang, CY, Ma, H, Chen, DY, Zhao, MZ, Hu, SW |
| Contributors: | Ci, YX (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Dept Chem, Beijing 100871, Peoples R China., Tsing Hua Univ, Dept Phys, Beijing 100084, Peoples R China., Inst Noble Met, Kunming, Peoples R China. |
| Source: | EI ; SCI ; PubMed |
| Publisher Information: | talanta |
| Publication Year: | 2001 |
| Collection: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| Subject Terms: | Cisplatin-liposome, Hela cells, voltammetry, DNA |
| Description: | In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells. (C) 2001 Elsevier Science B.V. All rights reserved. ; Chemistry, Analytical ; SCI(E) ; EI ; PubMed ; 10 ; ARTICLE ; 4 ; 693-698 ; 55 |
| Document Type: | journal/newspaper |
| Language: | English |
| ISBN: | 978-0-00-173288-9 0-00-173288-9 |
| Relation: | 672051; https://hdl.handle.net/20.500.11897/150188; WOS:000173288900005 |
| DOI: | 10.1016/S0039-9140(01)00480-5 |
| Availability: | https://hdl.handle.net/20.500.11897/150188 https://doi.org/10.1016/S0039-9140(01)00480-5 |
| Accession Number: | edsbas.B39C3625 |
| Database: | BASE |
| ISBN: | 9780001732889 0001732889 |
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| DOI: | 10.1016/S0039-9140(01)00480-5 |