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HC-IgA antibodies of different specificities are normally present in serum : quantitation by ELISA and relationship to the major Ig classes

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Τίτλος: HC-IgA antibodies of different specificities are normally present in serum : quantitation by ELISA and relationship to the major Ig classes
Συγγραφείς: Truedsson, Lennart, Karypidis, Anna-Helena, Eberhardt, Kerstin, Grubb, Anders
Πηγή: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica; 98(1-6), pp 249-254 (1990) ; ISSN: 0903-4641
Στοιχεία εκδότη: Blackwell Munksgaard
Έτος έκδοσης: 1990
Συλλογή: Lund University Publications (LUP)
Θεματικοί όροι: Clinical Medicine, Alpha-Globulins/analysis, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin A/analysis, Immunoglobulin G/analysis, Immunoglobulin M/analysis, Macromolecular Substances, Rheumatoid Factor/analysis, Tetanus Toxoid/immunology, Yersinia enterocolitica/immunology
Περιγραφή: Enzyme-linked immunosorbent assays (ELISA) were developed for direct measurement of protein HC-IgA complexes (HC-IgA) in serum with antibody specificity for rabbit IgG (rheumatoid factor (RF) activity), lipopolysaccharide from Yersinia enterocolitica serotype O:3 (Y3) and tetanus toxoid (TT). About 80% of patients with rheumatoid arthritis had increased concentrations of HC-IgA-RF. The values were correlated with the concentrations of IgA-RF and IgM-RF. HC-IgA anti-Y3 was measured in 45 sera with anti-Y3 antibodies of IgM, IgG and IgA class. The HC-IgA anti-Y3 levels were correlated with those of anti-Y3 of IgG and IgM class, but not of IgA class. For HC-IgA anti-Y3, the closest correlation was that with the specific IgM antibody concentration, rs = 0.63 (p less than 0.001). In 25 normal sera, significant correlations were observed between HC-IgA anti-TT and specific antibodies of IgG and IgA class, but not of IgM class. In 107 sera containing IgA M-components, the total concentration of HC-IgA correlated poorly with both protein HC and with IgA concentrations. It was concluded that specific HC-IgA antibodies are normal constituents of serum, and that their concentrations are not directly related to the serum content of specific IgA antibodies.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: scopus:0025233968; pmid:1690557
DOI: 10.1111/j.1699-0463.1990.tb01029.x
Διαθεσιμότητα: https://lup.lub.lu.se/record/6fbf7cd8-995a-4297-92aa-08829042687b
https://doi.org/10.1111/j.1699-0463.1990.tb01029.x
Αριθμός Καταχώρησης: edsbas.B2CC27B3
Βάση Δεδομένων: BASE
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  Data: HC-IgA antibodies of different specificities are normally present in serum : quantitation by ELISA and relationship to the major Ig classes
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  Data: <searchLink fieldCode="AR" term="%22Truedsson%2C+Lennart%22">Truedsson, Lennart</searchLink><br /><searchLink fieldCode="AR" term="%22Karypidis%2C+Anna-Helena%22">Karypidis, Anna-Helena</searchLink><br /><searchLink fieldCode="AR" term="%22Eberhardt%2C+Kerstin%22">Eberhardt, Kerstin</searchLink><br /><searchLink fieldCode="AR" term="%22Grubb%2C+Anders%22">Grubb, Anders</searchLink>
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  Data: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica; 98(1-6), pp 249-254 (1990) ; ISSN: 0903-4641
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  Data: Blackwell Munksgaard
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  Data: 1990
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  Data: Lund University Publications (LUP)
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  Data: <searchLink fieldCode="DE" term="%22Clinical+Medicine%22">Clinical Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Alpha-Globulins%2Fanalysis%22">Alpha-Globulins/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-Linked+Immunosorbent+Assay%22">Enzyme-Linked Immunosorbent Assay</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+A%2Fanalysis%22">Immunoglobulin A/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+G%2Fanalysis%22">Immunoglobulin G/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+M%2Fanalysis%22">Immunoglobulin M/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Macromolecular+Substances%22">Macromolecular Substances</searchLink><br /><searchLink fieldCode="DE" term="%22Rheumatoid+Factor%2Fanalysis%22">Rheumatoid Factor/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Tetanus+Toxoid%2Fimmunology%22">Tetanus Toxoid/immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Yersinia+enterocolitica%2Fimmunology%22">Yersinia enterocolitica/immunology</searchLink>
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  Data: Enzyme-linked immunosorbent assays (ELISA) were developed for direct measurement of protein HC-IgA complexes (HC-IgA) in serum with antibody specificity for rabbit IgG (rheumatoid factor (RF) activity), lipopolysaccharide from Yersinia enterocolitica serotype O:3 (Y3) and tetanus toxoid (TT). About 80% of patients with rheumatoid arthritis had increased concentrations of HC-IgA-RF. The values were correlated with the concentrations of IgA-RF and IgM-RF. HC-IgA anti-Y3 was measured in 45 sera with anti-Y3 antibodies of IgM, IgG and IgA class. The HC-IgA anti-Y3 levels were correlated with those of anti-Y3 of IgG and IgM class, but not of IgA class. For HC-IgA anti-Y3, the closest correlation was that with the specific IgM antibody concentration, rs = 0.63 (p less than 0.001). In 25 normal sera, significant correlations were observed between HC-IgA anti-TT and specific antibodies of IgG and IgA class, but not of IgM class. In 107 sera containing IgA M-components, the total concentration of HC-IgA correlated poorly with both protein HC and with IgA concentrations. It was concluded that specific HC-IgA antibodies are normal constituents of serum, and that their concentrations are not directly related to the serum content of specific IgA antibodies.
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  Data: 10.1111/j.1699-0463.1990.tb01029.x
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