Academic Journal
HC-IgA antibodies of different specificities are normally present in serum : quantitation by ELISA and relationship to the major Ig classes
| Title: | HC-IgA antibodies of different specificities are normally present in serum : quantitation by ELISA and relationship to the major Ig classes |
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| Authors: | Truedsson, Lennart, Karypidis, Anna-Helena, Eberhardt, Kerstin, Grubb, Anders |
| Source: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica; 98(1-6), pp 249-254 (1990) ; ISSN: 0903-4641 |
| Publisher Information: | Blackwell Munksgaard |
| Publication Year: | 1990 |
| Collection: | Lund University Publications (LUP) |
| Subject Terms: | Clinical Medicine, Alpha-Globulins/analysis, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin A/analysis, Immunoglobulin G/analysis, Immunoglobulin M/analysis, Macromolecular Substances, Rheumatoid Factor/analysis, Tetanus Toxoid/immunology, Yersinia enterocolitica/immunology |
| Description: | Enzyme-linked immunosorbent assays (ELISA) were developed for direct measurement of protein HC-IgA complexes (HC-IgA) in serum with antibody specificity for rabbit IgG (rheumatoid factor (RF) activity), lipopolysaccharide from Yersinia enterocolitica serotype O:3 (Y3) and tetanus toxoid (TT). About 80% of patients with rheumatoid arthritis had increased concentrations of HC-IgA-RF. The values were correlated with the concentrations of IgA-RF and IgM-RF. HC-IgA anti-Y3 was measured in 45 sera with anti-Y3 antibodies of IgM, IgG and IgA class. The HC-IgA anti-Y3 levels were correlated with those of anti-Y3 of IgG and IgM class, but not of IgA class. For HC-IgA anti-Y3, the closest correlation was that with the specific IgM antibody concentration, rs = 0.63 (p less than 0.001). In 25 normal sera, significant correlations were observed between HC-IgA anti-TT and specific antibodies of IgG and IgA class, but not of IgM class. In 107 sera containing IgA M-components, the total concentration of HC-IgA correlated poorly with both protein HC and with IgA concentrations. It was concluded that specific HC-IgA antibodies are normal constituents of serum, and that their concentrations are not directly related to the serum content of specific IgA antibodies. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | scopus:0025233968; pmid:1690557 |
| DOI: | 10.1111/j.1699-0463.1990.tb01029.x |
| Availability: | https://lup.lub.lu.se/record/6fbf7cd8-995a-4297-92aa-08829042687b https://doi.org/10.1111/j.1699-0463.1990.tb01029.x |
| Accession Number: | edsbas.B2CC27B3 |
| Database: | BASE |
| DOI: | 10.1111/j.1699-0463.1990.tb01029.x |
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