Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Significant inter- and intra-laboratory variation in grading of ductal carcinoma in situ of the breast: a nationwide study of 4901 patients in the Netherlands |
| Συγγραφείς: |
van Dooijeweert, Carmen, van Diest, Paul J., Willems, Stefan M., Kuijpers, Chantal C.H.J., Overbeek, Lucy I.H., Deckers, Ivette A.G., Pathologie Groep Van Diest, Cancer, Pathologie, Pathologie Pathologen staf, Pathologie Groep Moelans |
| Έτος έκδοσης: |
2019 |
| Θεματικοί όροι: |
DCIS, Ductal carcinoma in situ, Histologic grade, PALGA, Pathology, Prognostic factor, Carcinoma, Intraductal, Noninfiltrating/pathology, Breast Neoplasms/pathology, Humans, Middle Aged, Logistic Models, Netherlands, Neoplasm Grading, Female, Registries, Aged, Laboratories/standards, Odds Ratio, Oncology, Cancer Research, Journal Article, Comparative Study |
| Περιγραφή: |
Purpose: A considerable part of ductal carcinoma in situ (DCIS) lesions may never progress into invasive breast cancer. However, standard treatment consists of surgical excision. Trials aim to identify a subgroup of low-risk DCIS patients that can safely forgo surgical treatment based on histologic grade, which highlights the importance of accurate grading. Using real-life nationwide data, we aimed to create insight and awareness in grading variation of DCIS in daily clinical practice. Methods: All synoptic pathology reports of pure DCIS resection specimens between 2013 and 2016 were retrieved from PALGA, the nationwide Dutch Pathology Registry. Absolute differences in proportions of grade I-III were visualized using funnel plots. Multivariable analysis was performed by logistic regression to correct for case-mix, providing odds ratios and 95% confidence intervals for high-grade (III) versus low-grade (I–II) DCIS. Results: 4952 DCIS reports from 36 laboratories were included, of which 12.5% were reported as grade I (range 6.1–24.4%), 39.5% as grade II (18.2–57.6%), and 48.0% as grade III (30.2–72.7%). After correction for case-mix, 14 laboratories (38.9%) reported a significantly lower (n = 4) or higher (n = 10) proportion of high-grade DCIS than the reference laboratory. Adjusted ORs (95%CI) ranged from 0.52 (0.31–0.87) to 3.83 (1.42–10.39). Significant grading differences were also observed among pathologists within laboratories. Conclusion: In this cohort of 4901 patients, we observed substantial inter- and intra-laboratory variation in DCIS grading, not explained by differences in case-mix. Therefore, there is an urgent need for nationwide standardization of grading practices, especially since the future management of DCIS may alter significantly depending on histologic grade. |
| Τύπος εγγράφου: |
article in journal/newspaper |
| Περιγραφή αρχείου: |
text/plain |
| Γλώσσα: |
English |
| ISSN: |
0167-6806 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/391824 |
| Διαθεσιμότητα: |
https://dspace.library.uu.nl/handle/1874/391824 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Αριθμός Καταχώρησης: |
edsbas.AAA8AEED |
| Βάση Δεδομένων: |
BASE |