Dissertation/Thesis
Προβολή σε EDS

1389-2037/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. From Structure to Function: Methods and Applications

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: 1389-2037/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. From Structure to Function: Methods and Applications
Συγγραφείς: Haim J. Wolfson, Maxim Shatsky, Dina Schneidman-duhovny, Oranit Dror, Ra Shulman-peleg, Buyong Ma, Ruth Nussinov
Συνεισφορές: The Pennsylvania State University CiteSeerX Archives
Πηγή: http://www.cs.tau.ac.il/research/alex.shulman/papers/CurrProtPeptSci-05-Rev.pdf.
Συλλογή: CiteSeerX
Θεματικοί όροι: Structural pattern discovery, structural genomics, structure comparison, structural alignment, docking, drug design, conservation, flexible structural alignment, flexible docking, multiple structural alignment, folding, hinge-bending
Περιγραφή: The rapid increase in experimental data along with recent progress in computational methods has brought mod-ern biology a step closer toward solving one of the most challenging problems: prediction of protein function. Comprehen-sion of protein function at its most basic level requires understanding of molecular interactions. Currently, it is becoming universally accepted that the scale of the accumulated data for analysis and for prediction necessitate highly efficient com-putational tools with appropriate application capabilities. The review presents the up-to-date advances in computational methods for structural pattern discovery and for prediction of molecular associations. We focus on their applications toward a range of biological problems and highlight the advan-tages of the combination of these methods and their integration with biological experiments. We provide examples, syner-gistically merging structural modeling, rigid and flexible structural alignment and detection of conserved structural pat-terns and docking (rigid and flexible with hinge-bending movements). We hope the review will lead to a broader utiliza-tion of computational methods, and their cross-fertilization with experiment.
Τύπος εγγράφου: Thesis
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.456.1289
Διαθεσιμότητα: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.456.1289
http://www.cs.tau.ac.il/research/alex.shulman/papers/CurrProtPeptSci-05-Rev.pdf
Rights: Metadata may be used without restrictions as long as the oai identifier remains attached to it.
Αριθμός Καταχώρησης: edsbas.A552AB01
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
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  Data: 1389-2037/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. From Structure to Function: Methods and Applications
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  Data: <searchLink fieldCode="AR" term="%22Haim+J%2E+Wolfson%22">Haim J. Wolfson</searchLink><br /><searchLink fieldCode="AR" term="%22Maxim+Shatsky%22">Maxim Shatsky</searchLink><br /><searchLink fieldCode="AR" term="%22Dina+Schneidman-duhovny%22">Dina Schneidman-duhovny</searchLink><br /><searchLink fieldCode="AR" term="%22Oranit+Dror%22">Oranit Dror</searchLink><br /><searchLink fieldCode="AR" term="%22Ra+Shulman-peleg%22">Ra Shulman-peleg</searchLink><br /><searchLink fieldCode="AR" term="%22Buyong+Ma%22">Buyong Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Ruth+Nussinov%22">Ruth Nussinov</searchLink>
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  Data: <i>http://www.cs.tau.ac.il/research/alex.shulman/papers/CurrProtPeptSci-05-Rev.pdf</i>.
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  Data: <searchLink fieldCode="DE" term="%22Structural+pattern+discovery%22">Structural pattern discovery</searchLink><br /><searchLink fieldCode="DE" term="%22structural+genomics%22">structural genomics</searchLink><br /><searchLink fieldCode="DE" term="%22structure+comparison%22">structure comparison</searchLink><br /><searchLink fieldCode="DE" term="%22structural+alignment%22">structural alignment</searchLink><br /><searchLink fieldCode="DE" term="%22docking%22">docking</searchLink><br /><searchLink fieldCode="DE" term="%22drug+design%22">drug design</searchLink><br /><searchLink fieldCode="DE" term="%22conservation%22">conservation</searchLink><br /><searchLink fieldCode="DE" term="%22flexible+structural+alignment%22">flexible structural alignment</searchLink><br /><searchLink fieldCode="DE" term="%22flexible+docking%22">flexible docking</searchLink><br /><searchLink fieldCode="DE" term="%22multiple+structural+alignment%22">multiple structural alignment</searchLink><br /><searchLink fieldCode="DE" term="%22folding%22">folding</searchLink><br /><searchLink fieldCode="DE" term="%22hinge-bending%22">hinge-bending</searchLink>
– Name: Abstract
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  Data: The rapid increase in experimental data along with recent progress in computational methods has brought mod-ern biology a step closer toward solving one of the most challenging problems: prediction of protein function. Comprehen-sion of protein function at its most basic level requires understanding of molecular interactions. Currently, it is becoming universally accepted that the scale of the accumulated data for analysis and for prediction necessitate highly efficient com-putational tools with appropriate application capabilities. The review presents the up-to-date advances in computational methods for structural pattern discovery and for prediction of molecular associations. We focus on their applications toward a range of biological problems and highlight the advan-tages of the combination of these methods and their integration with biological experiments. We provide examples, syner-gistically merging structural modeling, rigid and flexible structural alignment and detection of conserved structural pat-terns and docking (rigid and flexible with hinge-bending movements). We hope the review will lead to a broader utiliza-tion of computational methods, and their cross-fertilization with experiment.
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      – Text: English
    Subjects:
      – SubjectFull: Structural pattern discovery
        Type: general
      – SubjectFull: structural genomics
        Type: general
      – SubjectFull: structure comparison
        Type: general
      – SubjectFull: structural alignment
        Type: general
      – SubjectFull: docking
        Type: general
      – SubjectFull: drug design
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      – SubjectFull: conservation
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      – SubjectFull: flexible structural alignment
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      – SubjectFull: flexible docking
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      – SubjectFull: multiple structural alignment
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      – SubjectFull: folding
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      – SubjectFull: hinge-bending
        Type: general
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      – TitleFull: 1389-2037/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. From Structure to Function: Methods and Applications
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