Dissertation/Thesis
1389-2037/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. From Structure to Function: Methods and Applications
| Τίτλος: | 1389-2037/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. From Structure to Function: Methods and Applications |
|---|---|
| Συγγραφείς: | Haim J. Wolfson, Maxim Shatsky, Dina Schneidman-duhovny, Oranit Dror, Ra Shulman-peleg, Buyong Ma, Ruth Nussinov |
| Συνεισφορές: | The Pennsylvania State University CiteSeerX Archives |
| Πηγή: | http://www.cs.tau.ac.il/research/alex.shulman/papers/CurrProtPeptSci-05-Rev.pdf. |
| Συλλογή: | CiteSeerX |
| Θεματικοί όροι: | Structural pattern discovery, structural genomics, structure comparison, structural alignment, docking, drug design, conservation, flexible structural alignment, flexible docking, multiple structural alignment, folding, hinge-bending |
| Περιγραφή: | The rapid increase in experimental data along with recent progress in computational methods has brought mod-ern biology a step closer toward solving one of the most challenging problems: prediction of protein function. Comprehen-sion of protein function at its most basic level requires understanding of molecular interactions. Currently, it is becoming universally accepted that the scale of the accumulated data for analysis and for prediction necessitate highly efficient com-putational tools with appropriate application capabilities. The review presents the up-to-date advances in computational methods for structural pattern discovery and for prediction of molecular associations. We focus on their applications toward a range of biological problems and highlight the advan-tages of the combination of these methods and their integration with biological experiments. We provide examples, syner-gistically merging structural modeling, rigid and flexible structural alignment and detection of conserved structural pat-terns and docking (rigid and flexible with hinge-bending movements). We hope the review will lead to a broader utiliza-tion of computational methods, and their cross-fertilization with experiment. |
| Τύπος εγγράφου: | Thesis |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.456.1289 |
| Διαθεσιμότητα: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.456.1289 http://www.cs.tau.ac.il/research/alex.shulman/papers/CurrProtPeptSci-05-Rev.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Αριθμός Καταχώρησης: | edsbas.A552AB01 |
| Βάση Δεδομένων: | BASE |
| Η περιγραφή δεν είναι διαθέσιμη |