Bibliographic Details
| Title: |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| Authors: |
Takeuchi, F. (Fumihiko), Akiyama, M. (Masato), Matoba, N. (Nana), Katsuya, T. (Tomohiro), Nakatochi, M. (Masahiro), Tabara, Y. (Yasuharu), Narita, A. (Akira), Saw, W.-Y. (Woei-Yuh), Moon, S. (Sanghoon), Spracklen, C. N. (Cassandra N.), Chai, J.-F. (Jin-Fang), Kim, Y.-J. (Young-Jin), Zhang, L. (Liang), Wang, C. (Chaolong), Li, H. (Huaixing), Li, H. (Honglan), Wu, J.-Y. (Jer-Yuarn), Dorajoo, R. (Rajkumar), Nierenberg, J. L. (Jovia L.), Wang, Y. X. (Ya Xing), He, J. (Jing), Bennett, D. A. (Derrick A.), Takahashi, A. (Atsushi), Momozawa, Y. (Yukihide), Hirata, M. (Makoto), Matsuda, K. (Koichi), Rakugi, H. (Hiromi), Nakashima, E. (Eitaro), Isono, M. (Masato), Shirota, M. (Matsuyuki), Hozawa, A. (Atsushi), Ichihara, S. (Sahoko), Matsubara, T. (Tatsuaki), Yamamoto, K. (Ken), Kohara, K. (Katsuhiko), Igase, M. (Michiya), Han, S. (Sohee), Gordon-Larsen, P. (Penny), Huang, W. (Wei), Lee, N. R. (Nanette R.), Adair, L. S. (Linda S.), Hwang, M. Y. (Mi Yeong), Lee, J. (Juyoung), Chee, M. L. (Miao Li), Sabanayagam, C. (Charumathi), Zhao, W. (Wanting), Liu, J. (Jianjun), Reilly, D. F. (Dermot F.), Sun, L. (Liang), Huo, S. (Shaofeng), Edwards, T. L. (Todd L.), Long, J. (Jirong), Chang, L.-C. (Li-Ching), Chen, C.-H. (Chien-Hsiun), Yuan, J.-M. (Jian-Min), Koh, W.-P. (Woon-Puay), Friedlander, Y. (Yechiel), Kelly, T. N. (Tanika N.), Wei, W. B. (Wen Bin), Xu, L. (Liang), Cai, H. (Hui), Xiang, Y.-B. (Yong-Bing), Lin, K. (Kuang), Clarke, R. (Robert), Walters, R. G. (Robin G.), Millwood, I. Y. (Iona Y.), Li, L. (Liming), Chambers, J. C. (John C.), Kooner, J. S. (Jaspal S.), Elliott, P. (Paul), van der Harst, P. (Pim), T. I. (The International Genomics of Blood Pressure (iGEN-BP) Consortium), Chen, Z. (Zhengming), Sasaki, M. (Makoto), Shu, X.-O. (Xiao-Ou), Jonas, J. B. (Jost B.), He, J. (Jiang), Heng, C.-K. (Chew-Kiat), Chen, Y.-T. (Yuan-Tsong), Wong, T. Y. (Tien Yin), Sim, X. (Xueling), Mohlke, K. L. (Karen L.), Yamamoto, M. (Masayuki), Kim, B.-J. (Bong-Jo), Miki, T. (Tetsuro), Nabika, T. (Toru), Yokota, M. (Mitsuhiro), Kamatani, Y. (Yoichiro), Kubo, M. (Michiaki), Kato, N. (Norihiro) |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2018 |
| Collection: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| Description: |
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. ; Acknowledgements Marie Loh71,72 (Institute of Health Sciences, University of Oulu, P.O.Box 5000FI-90014 Oulu, Finland and Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK), Niek Verweij73 (Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands), Weihua Zhang72,74 (Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK and Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK), Benjamin Lehne72 (Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK), Irene Mateo Leach73 (Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands), Alexander Drong75 (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK), James Abbott76 (Bioinformatics Support Service, Imperial College London, South Kensington, London SW7 2AZ, ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Availability: |
http://urn.fi/urn:nbn:fi-fe2020040110001 |
| Rights: |
info:eu-repo/semantics/openAccess ; © The Authors 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9977AA01 |
| Database: |
BASE |