Academic Journal
Clinicopathologic study of 60 cases of urothelial neoplasms with inverted growth patterns: Reclassification by international consultation on urologic disease (ICUD) recommendations
| Τίτλος: | Clinicopathologic study of 60 cases of urothelial neoplasms with inverted growth patterns: Reclassification by international consultation on urologic disease (ICUD) recommendations |
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| Συνεισφορές: | Heejin Bang, Heejung Park, Sanghui Park, Euno Choi, Min-Sun Cho, Sun Hee Sung, Sun Young Choi, Yong Mee Cho, Se Un Jeong, Jae Y Ro, Park, Heejung |
| Στοιχεία εκδότη: | W.B. Saunders Co. |
| Έτος έκδοσης: | 2020 |
| Θεματικοί όροι: | Adult, Aged, Biomarkers, Tumor / metabolism, Carcinoma, Papillary / pathology, Female, Humans, Hyperplasia / classification, Hyperplasia / pathology, Immunohistochemistry, Keratin-20 / metabolism, Ki-67 Antigen / metabolism, Male, Middle Aged, Neoplasm Grading, Papilloma, Inverted, Receptor, ErbB-2 / metabolism, Urinary Bladder / pathology, Urologic Diseases / classification, Urologic Diseases / pathology, Urologic Neoplasms / classification, Urologic Neoplasms / pathology, Urothelium / pathology, Inverted papillary neoplasm, Endophytic growth, Mitoses |
| Περιγραφή: | Background: Most urothelial neoplasms of the bladder show an exophytic papillary pattern, but some show an inverted growth pattern. In 2004, the World Health Organization (WHO) released a detailed histologic classification system for papillary urothelial neoplasms, but not for inverted forms. The International Consultation on Urologic Disease (ICUD) recommendations of 2012 are applicable to inverted/endophytic papillary lesions as follows: 1) inverted papilloma (IP), 2) inverted papillary urothelial neoplasm of low malignant potential (IPUNLMP), 3) inverted papillary urothelial carcinoma, low grade, non-invasive (IPUCLG-NI), 4) inverted papillary urothelial carcinoma, high grade, non-invasive (IPUCHG-NI), 5) inverted papillary urothelial carcinoma, high grade, invasive (IPUCHG-I). However, only atypical cellular morphology was considered for classification in the 2012 ICUD recommendations, and data to support to validate this new grading system are lacking. Methods: Sixty cases of inverted urothelial papillary tumors were classified into 5 categories according to 2012 ICUD and 2016 WHO/ISUP recommendations to evaluate their clinical, pathological, and immunohistochemical characteristics. Two subgroups were defined as subgroup 1, IP and IPUNLMP, and subgroup 2, IPUCLG-NI, IPUCHG-NI, and IPUCHG-I. Clinical features (age, sex, history of urothelial carcinoma, smoking history, size, and multifocality) and histologic features (nuclear pleomorphism, mitotic count, mitosis level, apoptosis, lumina] necrosis, trabecular thickening, anastomosing trabeculae, hypercellularity, loss of polarity, peripheral palisading, palisading with central streaming, and discohesiveness) were evaluated. Immunohistochemical stains for CK20, CD44, P53, p16, Ki-67, cyclin D1 and c-erbB2 were performed. Results: A total of 60 cases were classified as 10 cases of IP, 29 cases of IPUNLMPs, 15 cases of IPIJCLG-NI, 4 cases of IPUCHG-NI, and 2 cases of IPUCHG-I. Compared to subgroup 1, subgroup 2 showed larger tumor size, more nuclear ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | ANNALS OF DIAGNOSTIC PATHOLOGY; J04260; https://ir.ymlib.yonsei.ac.kr/handle/22282913/190211; https://www.sciencedirect.com/science/article/pii/S1092913419303624; T9992020436 |
| DOI: | 10.1016/j.anndiagpath.2019.151433 |
| Διαθεσιμότητα: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190211 https://doi.org/10.1016/j.anndiagpath.2019.151433 https://www.sciencedirect.com/science/article/pii/S1092913419303624 |
| Rights: | CC BY-NC-ND 2.0 KR |
| Αριθμός Καταχώρησης: | edsbas.981D9AE0 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1016/j.anndiagpath.2019.151433 |
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