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Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography

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Τίτλος: Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography
Συγγραφείς: Ren, Wuwei, Deán-Ben, Xosé Luís, Skachokova, Zhiva, Augath, Mark-Aurel, Ni, Ruiqing, Chen, Zhenyue, Razansky, Daniel
Πηγή: Ren, W., Deán-Ben, X. L., Skachokova, Z., Augath, M.-A., Ni, R., Chen, Z., & Razansky, D. (2023). Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography. Biomedical Optics Express, 14, 1192–1204. https://doi.org/10.1364/BOE.482205
Στοιχεία εκδότη: Optical Society of America
Έτος έκδοσης: 2023
Συλλογή: University of Zurich (UZH): ZORA (Zurich Open Repository and Archive
Θεματικοί όροι: 170 Ethics, 610 Medicine & health
Περιγραφή: Progress in brain research critically depends on the development of next-generation multi-modal imaging tools capable of capturing transient functional events and multiplexed contrasts noninvasively and concurrently, thus enabling a holistic view of dynamic events in vivo. Here we report on a hybrid magnetic resonance and optoacoustic tomography (MROT) system for murine brain imaging, which incorporates an MR-compatible spherical matrix array transducer and fiber-based light illumination into a 9.4 T small animal scanner. An optimized radiofrequency coil has further been devised for whole-brain interrogation. System's utility is showcased by acquiring complementary angiographic and soft tissue anatomical contrast along with simultaneous dual-modality visualization of contrast agent dynamics in vivo.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
ISSN: 2156-7085
Relation: info:pmid/36950237; urn:issn:2156-7085
DOI: 10.1364/BOE.482205
Διαθεσιμότητα: https://www.zora.uzh.ch/handle/20.500.14742/208671
https://hdl.handle.net/20.500.14742/208671
https://doi.org/10.1364/BOE.482205
Rights: info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/
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Βάση Δεδομένων: BASE
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  Data: Ren, W., Deán-Ben, X. L., Skachokova, Z., Augath, M.-A., Ni, R., Chen, Z., & Razansky, D. (2023). Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography. Biomedical Optics Express, 14, 1192–1204. https://doi.org/10.1364/BOE.482205
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  Data: Progress in brain research critically depends on the development of next-generation multi-modal imaging tools capable of capturing transient functional events and multiplexed contrasts noninvasively and concurrently, thus enabling a holistic view of dynamic events in vivo. Here we report on a hybrid magnetic resonance and optoacoustic tomography (MROT) system for murine brain imaging, which incorporates an MR-compatible spherical matrix array transducer and fiber-based light illumination into a 9.4 T small animal scanner. An optimized radiofrequency coil has further been devised for whole-brain interrogation. System's utility is showcased by acquiring complementary angiographic and soft tissue anatomical contrast along with simultaneous dual-modality visualization of contrast agent dynamics in vivo.
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