Academic Journal
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
| Title: | Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group |
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| Authors: | Harrewijn, A, Cardinale, EM, Groenewold, NA, Bas-Hoogendam, JM, Aghajani, M, Hilbert, K, Cardoner, N, Porta-Casteràs, D, Gosnell, S, Salas, R, Jackowski, AP, Pan, PM, Salum, GA, Blair, KS, Blair, JR, Hammoud, MZ, Milad, MR, Burkhouse, KL, Phan, KL, Schroeder, HK, Strawn, JR, Beesdo-Baum, K, Jahanshad, N, Thomopoulos, SI, Buckner, R, Nielsen, JA, Smoller, JW, Soares, JC, Mwangi, B, Wu, MJ, Zunta-Soares, GB, Assaf, M, Diefenbach, GJ, Brambilla, P, Maggioni, E, Hofmann, D, Straube, T, Andreescu, C, Berta, R, Tamburo, E, Price, RB, Manfro, GG, Agosta, F, Canu, E, Cividini, C, Filippi, M, Kostić, M, Munjiza Jovanovic, A, Alberton, BAV, Benson, B, Freitag, GF, Filippi, CA, Gold, AL, Leibenluft, E, Ringlein, GV, Werwath, KE, Zwiebel, H, Zugman, A, Grabe, HJ, Van der Auwera, S, Wittfeld, K, Völzke, H, Bülow, R, Balderston, NL, Ernst, M, Grillon, C, Mujica-Parodi, LR, van Nieuwenhuizen, H, Critchley, HD, Makovac, E, Mancini, M, Meeten, F, Ottaviani, C, Ball, TM, Fonzo, GA, Paulus, MP, Stein, MB, Gur, RE, Gur, RC, Kaczkurkin, AN, Larsen, B, Satterthwaite, TD, Harper, J, Myers, M, Perino, MT, Sylvester, CM, Yu, Q, Lueken, U, Veltman, DJ, Thompson, PM, Stein, DJ, Van der Wee, NJA, Winkler, AM, Pine, DS |
| Publisher Information: | Springer Nature |
| Publication Year: | 2021 |
| Collection: | Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: | neuroscience, psychology |
| Description: | A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/principal-investigators.html. ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. ; Supplementary information is available online at: https://www.nature.com/articles/s41398-021-01622-1#Sec12 . ; The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5–90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ, years of education, medication use, comorbidities, and global brain measures. The main analysis (1020 individuals with GAD and 2999 healthy controls) included random slopes per site and random intercepts per scanner. A secondary analysis (1112 individuals with GAD and 3282 healthy controls) included fixed slopes and random intercepts per scanner with the same variables. The main analysis showed no effect of GAD on brain structure, nor interactions involving GAD, age, or sex. The secondary analysis showed increased volume in the right ventral diencephalon in male individuals with GAD compared to male healthy controls, whereas female individuals with GAD did not differ from female healthy controls. This mega-analysis combining worldwide data showed that differences in brain structure related to GAD are ... |
| Document Type: | article in journal/newspaper |
| File Description: | 1 - 15; Electronic |
| Language: | English |
| Relation: | Translational Psychiatry; 502; https://bura.brunel.ac.uk/handle/2438/30083 |
| DOI: | 10.1038/s41398-021-01622-1 |
| Availability: | https://bura.brunel.ac.uk/handle/2438/30083 https://doi.org/10.1038/s41398-021-01622-1 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/legalcode.en ; The Author(s) |
| Accession Number: | edsbas.92EDAD19 |
| Database: | BASE |
| DOI: | 10.1038/s41398-021-01622-1 |
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