Academic Journal
Diagnostic Performance of PI-RADS v2.1 for Clinically Significant Prostate Cancer in Indonesian Patients Undergoing MRI Fusion Prostate Biopsy
| Τίτλος: | Diagnostic Performance of PI-RADS v2.1 for Clinically Significant Prostate Cancer in Indonesian Patients Undergoing MRI Fusion Prostate Biopsy |
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| Συγγραφείς: | Sindunata, Nyoman Aditya, Tarigan, Vera Nevyta, Jorisal, Patricia, Murtala, Bachtiar, Sugiono, Marto, Sungono, Veli |
| Πηγή: | Medicinus; Vol. 15 No. 2 (2026): February; 41–47 ; 2622-6995 ; 1978-3094 |
| Στοιχεία εκδότη: | Fakultas Kedokteran Universitas Pelita Harapan |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | UPH Academic Journals (Universitas Pelita Harapan) |
| Θεματικοί όροι: | Diagnostic performance, MRI fusion prostate biopsy, PI-RADS v2.1, prostate cancer |
| Περιγραφή: | Background: Prostate cancer is the second most common malignancy among men and one of the leading causes of cancer-related death. MRI evaluation using prostate imaging and data system (PI-RADS) v2.1 is widely applied to detect clinically significant prostate cancer (csPCa). However, data on its diagnostic performance in Indonesian population remain limited. Methods: An analytical observational study with retrospective cross-sectional design was conducted on patients with PI-RADS category 3-5 who underwent MRI fusion prostate biopsy at Siloam Hospitals Kebon Jeruk between 2021 and 2025. Sensitivity, specificity, predictive values, and accuracy of PI-RADS v2.1 were evaluated against histopathological findings. Statistical analyses include Chi-Square and Mann-Whitney U test. Result: A total of 75 patients were included, with a median age of 71 years (range: 49-84). The csPCa detection rates for each PI-RADS category were 14.29% for PI-RADS 3, 48.28% for PI-RADS 4 and 89.74% for PI-RADS 5. Histopathology confirmed csPCa in 50 patients (66.67%) and non-csPCa or benign lesions in 25 patients. The sensitivity of PI-RADS v2.1 at a cutoff ≥4 was 98% (95% CI 89.35–99.95), specificity 24% (95% CI 9.36–45.13), positive predictive value (PPV) 72.06%, negative predictive value (NPV) 85.71%, and overall accuracy 73.33% (95% CI 61.86–82.89). Bivariate analysis showed that older age, higher PSA, larger lesion size, PSA density ≥0.15 ng/ml2, and PIRADS 4/5 category were significantly associated with csPCa. Conclusions: PI-RADS v2.1 demonstrates very high sensitivity and good NPV for excluding csPCa but has low specificity, resulting in moderate overall accuracy (73.33%). |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://ojs.uph.edu/index.php/MED/article/view/10777/5604; https://ojs.uph.edu/index.php/MED/article/view/10777 |
| DOI: | 10.19166/med.v15i2.10777 |
| Διαθεσιμότητα: | https://ojs.uph.edu/index.php/MED/article/view/10777 https://doi.org/10.19166/med.v15i2.10777 |
| Rights: | Copyright (c) 2026 Nyoman Aditya Sindunata, Vera Nevyta Tarigan, Patricia Jorisal, Bachtiar Murtala, Marto Sugiono, Veli Sungono ; http://creativecommons.org/licenses/by-sa/4.0 |
| Αριθμός Καταχώρησης: | edsbas.8C51E2FE |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.19166/med.v15i2.10777 |
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